GO Annotations Graph

• Symbol: Aif1
• Name: allograft inflammatory factor 1
• ID: MGI:1343098

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0051015	actin filament binding	IMP	J:269679
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	IDA	J:182386
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:90132
Molecular Function	GO:0005515	protein binding	IPI	J:90132
Molecular Function	GO:0005515	protein binding	IPI	J:90132
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0005884	actin filament	IDA	J:90132
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:182420
Cellular Component	GO:0005737	cytoplasm	IDA	J:90132
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0097386	glial cell projection	IDA	J:90132
Cellular Component	GO:0030027	lamellipodium	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	IDA	J:182420
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:182420
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0001891	phagocytic cup	IDA	J:182420
Cellular Component	GO:0001891	phagocytic cup	IDA	J:90132
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0001726	ruffle	IDA	J:90132
Cellular Component	GO:0032587	ruffle membrane	IDA	J:182420
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	IBA	J:265628
Biological Process	GO:0051764	actin crosslink formation	IMP	J:269679
Biological Process	GO:0051017	actin filament bundle assembly	ISO	J:164563
Biological Process	GO:0051017	actin filament bundle assembly	IBA	J:265628
Biological Process	GO:0051017	actin filament bundle assembly	IDA	J:90132
Biological Process	GO:0030041	actin filament polymerization	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0001774	microglial cell activation	NAS	J:182386
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0071672	negative regulation of smooth muscle cell chemotaxis	ISO	J:164563
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0030046	parallel actin filament bundle assembly	IDA	J:269679
Biological Process	GO:0006911	phagocytosis, engulfment	IMP	J:182420
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0050921	positive regulation of chemotaxis	ISO	J:164563
Biological Process	GO:0090271	positive regulation of fibroblast growth factor production	ISO	J:164563
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	ISO	J:164563
Biological Process	GO:0071677	positive regulation of mononuclear cell migration	ISO	J:164563
Biological Process	GO:0014739	positive regulation of muscle hyperplasia	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0071673	positive regulation of smooth muscle cell chemotaxis	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:2000406	positive regulation of T cell migration	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0016601	Rac protein signal transduction	IMP	J:182420
Biological Process	GO:0097178	ruffle assembly	NAS	J:182386
Biological Process	GO:0097178	ruffle assembly	IMP	J:182420
Biological Process	GO:0097178	ruffle assembly	IBA	J:265628