GO Annotations Graph

• Symbol: Hpse
• Name: heparanase
• ID: MGI:1343124

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140355	cargo receptor ligand activity	ISO	J:324696
Molecular Function	GO:0030305	heparanase activity	ISO	J:164563
Molecular Function	GO:0030305	heparanase activity	ISO	J:164563
Molecular Function	GO:0030305	heparanase activity	ISO	J:155856
Molecular Function	GO:0030305	heparanase activity	IDA	J:293570
Molecular Function	GO:0030305	heparanase activity	IDA	J:81602
Molecular Function	GO:0030305	heparanase activity	ISO	J:56032
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	J:72247
Molecular Function	GO:0045545	syndecan binding	ISO	J:164563
Cellular Component	GO:0005776	autophagosome	NAS	J:283458
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	IBA	J:265628
Cellular Component	GO:0031012	extracellular matrix	TAS	J:56032
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:293570
Cellular Component	GO:1904974	heparanase complex	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0043202	lysosomal lumen	ISO	J:324765
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0045121	membrane raft	IDA	J:124228
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:124228
Cellular Component	GO:0005634	nucleus	IDA	J:97080
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:324696
Biological Process	GO:0060055	angiogenesis involved in wound healing	IDA	J:97080
Biological Process	GO:0060055	angiogenesis involved in wound healing	IBA	J:265628
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0061028	establishment of endothelial barrier	IDA	J:293570
Biological Process	GO:0002542	Factor XII activation	ISO	J:164563
Biological Process	GO:0030200	heparan sulfate proteoglycan catabolic process	ISO	J:164563
Biological Process	GO:0030200	heparan sulfate proteoglycan catabolic process	IDA	J:81602
Biological Process	GO:0030202	heparin metabolic process	IDA	J:293570
Biological Process	GO:0030202	heparin metabolic process	IMP	J:293570
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0030194	positive regulation of blood coagulation	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0090091	positive regulation of extracellular matrix disassembly	NAS	J:320306
Biological Process	GO:0051798	positive regulation of hair follicle development	IDA	J:97080
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	ISO	J:164563
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	IDA	J:175154
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IDA	J:124228
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0071806	protein transmembrane transport	IMP	J:293570
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:324696
Biological Process	GO:0051797	regulation of hair follicle development	ISO	J:164563
Biological Process	GO:0010033	response to organic substance	IDA	J:297194
Biological Process	GO:0061042	vascular wound healing	IDA	J:97080
Biological Process	GO:0042060	wound healing	IDA	J:97080