GO Annotations Graph

• Symbol: Zeb1
• Name: zinc finger E-box binding homeobox 1
• ID: MGI:1344313

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	IDA	J:121427
Molecular Function	GO:0003682	chromatin binding	IDA	J:110800
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:213415
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0070888	E-box binding	IDA	J:164132
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:169126
Molecular Function	GO:0005515	protein binding	IPI	J:121427
Molecular Function	GO:0005515	protein binding	IPI	J:110800
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:164132
Cellular Component	GO:0005634	nucleus	IDA	J:86960
Biological Process	GO:0048856	anatomical structure development	IBA	J:265628
Biological Process	GO:0048513	animal organ development	IMP	J:106502
Biological Process	GO:0051216	cartilage development	IMP	J:45575
Biological Process	GO:0051216	cartilage development	IMP	J:45575
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0008283	cell population proliferation	IMP	J:135179
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:164409
Biological Process	GO:0007417	central nervous system development	IGI	J:108819
Biological Process	GO:0007417	central nervous system development	IGI	J:108819
Biological Process	GO:0090103	cochlea morphogenesis	IMP	J:177274
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	IMP	J:135179
Biological Process	GO:0048598	embryonic morphogenesis	IGI	J:108819
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	IMP	J:45575
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:135179
Biological Process	GO:0043616	keratinocyte proliferation	IMP	J:135179
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:164132
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	ISO	J:164563
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	IMP	J:131173
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	IMP	J:131173
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:135179
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	IMP	J:135179
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:121427
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0007389	pattern specification process	IMP	J:45575
Biological Process	GO:0007389	pattern specification process	IMP	J:45575
Biological Process	GO:0007389	pattern specification process	IMP	J:45575
Biological Process	GO:0007389	pattern specification process	IMP	J:45575
Biological Process	GO:0007389	pattern specification process	IMP	J:45575
Biological Process	GO:0007389	pattern specification process	IMP	J:45575
Biological Process	GO:0007389	pattern specification process	IMP	J:45575
Biological Process	GO:0045666	positive regulation of neuron differentiation	IDA	J:164132
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:110800
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:110800
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:110800
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:110800
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:110800
Biological Process	GO:0010464	regulation of mesenchymal cell proliferation	IMP	J:131173
Biological Process	GO:0051150	regulation of smooth muscle cell differentiation	IMP	J:110800
Biological Process	GO:0033081	regulation of T cell differentiation in thymus	IMP	J:45575
Biological Process	GO:0033081	regulation of T cell differentiation in thymus	IMP	J:39865
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	IGI	J:110800
Biological Process	GO:0048752	semicircular canal morphogenesis	IMP	J:177274