GO Annotations Graph

• Symbol: Grem1
• Name: gremlin 1, DAN family BMP antagonist
• ID: MGI:1344337

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0036122	BMP binding	ISO	J:164563
Molecular Function	GO:0036122	BMP binding	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	TAS	J:145361
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0048018	receptor ligand activity	IPI	J:166472
Molecular Function	GO:0048018	receptor ligand activity	IBA	J:265628
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	IDA	J:166472
Molecular Function	GO:0043184	vascular endothelial growth factor receptor 2 binding	IPI	J:166472
Cellular Component	GO:0009986	cell surface	IDA	J:145361
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:145361
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IDA	J:138423
Biological Process	GO:0009887	animal organ morphogenesis	IBA	J:265628
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:91385
Biological Process	GO:0055007	cardiac muscle cell differentiation	IDA	J:182488
Biological Process	GO:0060379	cardiac muscle cell myoblast differentiation	IDA	J:182488
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	IDA	J:145361
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	IDA	J:166472
Biological Process	GO:0000902	cell morphogenesis	ISO	J:164563
Biological Process	GO:0007267	cell-cell signaling	IMP	J:90991
Biological Process	GO:0007267	cell-cell signaling	IMP	J:90991
Biological Process	GO:0030199	collagen fibril organization	ISO	J:164563
Biological Process	GO:0048263	determination of dorsal identity	ISO	J:164563
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:84077
Biological Process	GO:0043542	endothelial cell migration	IDA	J:145361
Biological Process	GO:0060173	limb development	ISO	J:164563
Biological Process	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	IDA	J:122530
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IMP	J:122530
Biological Process	GO:0030502	negative regulation of bone mineralization	ISO	J:164563
Biological Process	GO:1900158	negative regulation of bone mineralization involved in bone maturation	ISO	J:164563
Biological Process	GO:0046851	negative regulation of bone remodeling	ISO	J:164563
Biological Process	GO:1900155	negative regulation of bone trabecula formation	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:155856
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:122530
Biological Process	GO:0002689	negative regulation of leukocyte chemotaxis	ISO	J:155856
Biological Process	GO:0090027	negative regulation of monocyte chemotaxis	ISO	J:155856
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:155856
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	ISO	J:164563
Biological Process	GO:0090291	negative regulation of osteoclast proliferation	ISO	J:164563
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:145361
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IDA	J:122530
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IDA	J:171473
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IGI	J:122530
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:122530
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	J:138423
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IDA	J:138423
Biological Process	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	IDA	J:166472
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	IDA	J:145361
Biological Process	GO:0002092	positive regulation of receptor internalization	IDA	J:166472
Biological Process	GO:2000273	positive regulation of signaling receptor activity	IDA	J:166472
Biological Process	GO:0051973	positive regulation of telomerase activity	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:183226
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:182488
Biological Process	GO:0009954	proximal/distal pattern formation	IMP	J:84077
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0051893	regulation of focal adhesion assembly	IDA	J:145361
Biological Process	GO:0038098	sequestering of BMP from receptor via BMP binding	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IDA	J:166472
Biological Process	GO:0060676	ureteric bud formation	IDA	J:122530