GO Annotations Graph

• Symbol: Zeb2
• Name: zinc finger E-box binding homeobox 2
• ID: MGI:1344407

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:219928
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070412	R-SMAD binding	IDA	J:106894
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:211299
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0048856	anatomical structure development	IBA	J:265628
Biological Process	GO:0021846	cell proliferation in forebrain	IMP	J:123406
Biological Process	GO:0007417	central nervous system development	IGI	J:108819
Biological Process	GO:0007417	central nervous system development	IGI	J:108819
Biological Process	GO:0048668	collateral sprouting	IMP	J:219928
Biological Process	GO:0021540	corpus callosum morphogenesis	IMP	J:219928
Biological Process	GO:0021957	corticospinal tract morphogenesis	IMP	J:219928
Biological Process	GO:0048066	developmental pigmentation	IMP	J:211299
Biological Process	GO:0048598	embryonic morphogenesis	IGI	J:108819
Biological Process	GO:0021766	hippocampus development	IMP	J:123406
Biological Process	GO:0061373	mammillary axonal complex development	IMP	J:219928
Biological Process	GO:0097324	melanocyte migration	IMP	J:211299
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:211299
Biological Process	GO:0001755	neural crest cell migration	IMP	J:82084
Biological Process	GO:0001843	neural tube closure	IMP	J:108819
Biological Process	GO:0050772	positive regulation of axonogenesis	IMP	J:219928
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IMP	J:123406
Biological Process	GO:1902748	positive regulation of lens fiber cell differentiation	IMP	J:101730
Biological Process	GO:0048023	positive regulation of melanin biosynthetic process	IC	J:211299
Biological Process	GO:0045636	positive regulation of melanocyte differentiation	IMP	J:211299
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:211299
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:219928
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	IMP	J:123406
Biological Process	GO:1903056	regulation of melanosome organization	IMP	J:211299
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0001756	somitogenesis	IMP	J:101030
Biological Process	GO:0001756	somitogenesis	IMP	J:108819