GO Annotations Graph

• Symbol: Spry2
• Name: sprouty RTK signaling antagonist 2
• ID: MGI:1345138

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:116930
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0005515	protein binding	IPI	J:73116
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IDA	J:225489
Cellular Component	GO:0005829	cytosol	IDA	J:225489
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0016020	membrane	IDA	J:225489
Cellular Component	GO:0005874	microtubule	IEA	J:60000
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:1990752	microtubule end	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:225489
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0048513	animal organ development	IBA	J:265628
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IMP	J:53234
Biological Process	GO:0060449	bud elongation involved in lung branching	IGI	J:174194
Biological Process	GO:0060449	bud elongation involved in lung branching	IGI	J:174194
Biological Process	GO:0045165	cell fate commitment	IMP	J:98303
Biological Process	GO:0045165	cell fate commitment	IGI	J:98303
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IGI	J:174194
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IGI	J:174194
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IGI	J:174194
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IGI	J:174194
Biological Process	GO:0000132	establishment of mitotic spindle orientation	IGI	J:174194
Biological Process	GO:0000132	establishment of mitotic spindle orientation	IGI	J:174194
Biological Process	GO:0000132	establishment of mitotic spindle orientation	IGI	J:174194
Biological Process	GO:0000132	establishment of mitotic spindle orientation	IGI	J:174194
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:98303
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:98303
Biological Process	GO:0042472	inner ear morphogenesis	IGI	J:98303
Biological Process	GO:0042472	inner ear morphogenesis	IMP	J:98303
Biological Process	GO:0030324	lung development	IMP	J:53234
Biological Process	GO:0060437	lung growth	IDA	J:69279
Biological Process	GO:0060425	lung morphogenesis	IDA	J:69279
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:131584
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IDA	J:73116
Biological Process	GO:0031345	negative regulation of cell projection organization	IDA	J:225489
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	IDA	J:287032
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IDA	J:287039
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IDA	J:225489
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IGI	J:174194
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IDA	J:73116
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IGI	J:174194
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	IGI	J:98303
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	IDA	J:73116
Biological Process	GO:0034260	negative regulation of GTPase activity	IDA	J:73116
Biological Process	GO:1902747	negative regulation of lens fiber cell differentiation	IDA	J:287039
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IBA	J:265628
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IDA	J:105250
Biological Process	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	IDA	J:73116
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	IBA	J:265628
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	IDA	J:73116
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IDA	J:287032
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0045595	regulation of cell differentiation	IEA	J:72247
Biological Process	GO:0042127	regulation of cell population proliferation	IEA	J:72247
Biological Process	GO:0009966	regulation of signal transduction	IEA	J:72247
Biological Process	GO:0060541	respiratory system development	IDA	J:69279
Biological Process	GO:0007605	sensory perception of sound	IMP	J:98303