GO Annotations Graph

• Symbol: Spry4
• Name: sprouty RTK signaling antagonist 4
• ID: MGI:1345144

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:130605
Molecular Function	GO:0005515	protein binding	IPI	J:116930
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0004860	protein kinase inhibitor activity	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0048513	animal organ development	IBA	J:265628
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IEA	J:72247
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IBA	J:265628
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IDA	J:105250
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	IBA	J:265628
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0009966	regulation of signal transduction	IEA	J:72247