GO Annotations Graph

• Symbol: Scn11a
• Name: sodium channel, voltage-gated, type XI, alpha
• ID: MGI:1345149

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005261	monoatomic cation channel activity	IEA	J:72247
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:69766
Molecular Function	GO:0005272	sodium channel activity	IEA	J:60000
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IBA	J:265628
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IDA	J:101093
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:185985
Cellular Component	GO:0030424	axon	IDA	J:101093
Cellular Component	GO:0044295	axonal growth cone	IDA	J:185985
Cellular Component	GO:0044299	C-fiber	IDA	J:101093
Cellular Component	GO:0044297	cell body	IDA	J:279469
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	IDA	J:123231
Cellular Component	GO:0043025	neuronal cell body	IMP	J:241829
Cellular Component	GO:0005886	plasma membrane	IDA	J:101093
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0001518	voltage-gated sodium channel complex	IBA	J:265628
Biological Process	GO:0001508	action potential	IMP	J:270913
Biological Process	GO:0099610	action potential initiation	IMP	J:216497
Biological Process	GO:0099610	action potential initiation	IMP	J:228461
Biological Process	GO:0099610	action potential initiation	IMP	J:268091
Biological Process	GO:0099610	action potential initiation	IMP	J:268091
Biological Process	GO:0099610	action potential initiation	IMP	J:268684
Biological Process	GO:0099610	action potential initiation	IMP	J:279469
Biological Process	GO:0002526	acute inflammatory response	IMP	J:279469
Biological Process	GO:0060840	artery development	IMP	J:279469
Biological Process	GO:0007409	axonogenesis	IMP	J:185985
Biological Process	GO:0007409	axonogenesis	IMP	J:185985
Biological Process	GO:0061367	behavioral response to acetic acid induced pain	IMP	J:157013
Biological Process	GO:0061368	behavioral response to formalin induced pain	IMP	J:157013
Biological Process	GO:0048266	behavioral response to pain	IMP	J:157013
Biological Process	GO:1990408	calcitonin gene-related peptide receptor signaling pathway	IMP	J:279469
Biological Process	GO:1990408	calcitonin gene-related peptide receptor signaling pathway	IMP	J:293872
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:185985
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:185985
Biological Process	GO:0048870	cell motility	IMP	J:241829
Biological Process	GO:0070417	cellular response to cold	IMP	J:228461
Biological Process	GO:0007635	chemosensory behavior	IMP	J:270913
Biological Process	GO:0002544	chronic inflammatory response	IMP	J:279469
Biological Process	GO:0007623	circadian rhythm	IMP	J:223160
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	IMP	J:223160
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	IMP	J:279469
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	IMP	J:279469
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	IMP	J:223160
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	IMP	J:228461
Biological Process	GO:0051649	establishment of localization in cell	IDA	J:101093
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IMP	J:141209
Biological Process	GO:0006954	inflammatory response	IMP	J:116768
Biological Process	GO:0006954	inflammatory response	IMP	J:146535
Biological Process	GO:0006954	inflammatory response	IMP	J:216497
Biological Process	GO:0006954	inflammatory response	IMP	J:241829
Biological Process	GO:0006954	inflammatory response	IMP	J:293872
Biological Process	GO:0043303	mast cell degranulation	IMP	J:279469
Biological Process	GO:0086010	membrane depolarization during action potential	IBA	J:265628
Biological Process	GO:0060073	micturition	IMP	J:146535
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0019228	neuronal action potential	IBA	J:265628
Biological Process	GO:0019228	neuronal action potential	IMP	J:116768
Biological Process	GO:0010737	protein kinase A signaling	IMP	J:279469
Biological Process	GO:0060004	reflex	IMP	J:123231
Biological Process	GO:0042391	regulation of membrane potential	IMP	J:268091
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0051930	regulation of sensory perception of pain	IMP	J:206848
Biological Process	GO:0010996	response to auditory stimulus	IMP	J:279469
Biological Process	GO:0009409	response to cold	IMP	J:268684
Biological Process	GO:1902518	response to cyclophosphamide	IMP	J:146535
Biological Process	GO:0009408	response to heat	IMP	J:268684
Biological Process	GO:0009644	response to high light intensity	IMP	J:279469
Biological Process	GO:0071731	response to nitric oxide	IMP	J:279469
Biological Process	GO:0048265	response to pain	IMP	J:116768
Biological Process	GO:0048265	response to pain	IMP	J:123231
Biological Process	GO:0048265	response to pain	IMP	J:268091
Biological Process	GO:0048265	response to pain	IMP	J:268091
Biological Process	GO:0048265	response to pain	IMP	J:268684
Biological Process	GO:0034695	response to prostaglandin E	IMP	J:146535
Biological Process	GO:0009636	response to toxic substance	IMP	J:141209
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:228461
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:279469
Biological Process	GO:0160025	sensory perception of itch	IMP	J:270913
Biological Process	GO:0160025	sensory perception of itch	IMP	J:293872
Biological Process	GO:0060538	skeletal muscle organ development	IMP	J:293872
Biological Process	GO:1990770	small intestine smooth muscle contraction	IMP	J:293872
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:141209
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:208111
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:216497
Biological Process	GO:0006814	sodium ion transport	IDA	J:101093
Biological Process	GO:0040040	thermosensory behavior	IMP	J:268684
Biological Process	GO:0001966	thigmotaxis	IMP	J:279469
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0019226	transmission of nerve impulse	IMP	J:99870