GO Annotations Graph

• Symbol: Sh2b2
• Name: SH2B adaptor protein 2
• ID: MGI:1345171

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:76351
Molecular Function	GO:0005515	protein binding	IPI	J:62510
Molecular Function	GO:0005515	protein binding	IPI	J:100934
Molecular Function	GO:0005515	protein binding	IPI	J:54187
Molecular Function	GO:0005515	protein binding	IPI	J:62510
Molecular Function	GO:0005515	protein binding	IPI	J:62510
Molecular Function	GO:0005515	protein binding	IPI	J:62510
Molecular Function	GO:0005515	protein binding	IPI	J:62510
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:164563
Molecular Function	GO:0035591	signaling adaptor activity	IDA	J:62510
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IBA	J:265628
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IDA	J:54187
Cellular Component	GO:0005884	actin filament	IDA	J:88527
Cellular Component	GO:0005737	cytoplasm	ISS	J:113810
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISS	J:113810
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0001726	ruffle	IDA	J:100934
Cellular Component	GO:0001725	stress fiber	IDA	J:100934
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:88527
Biological Process	GO:0030036	actin cytoskeleton organization	IPI	J:100934
Biological Process	GO:0050851	antigen receptor-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0050853	B cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:62510
Biological Process	GO:0001922	B-1 B cell homeostasis	IMP	J:88527
Biological Process	GO:0050873	brown fat cell differentiation	IDA	J:137608
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:62510
Biological Process	GO:0051649	establishment of localization in cell	ISA	J:86301
Biological Process	GO:0042593	glucose homeostasis	ISA	J:86301
Biological Process	GO:0046323	glucose import	ISA	J:86301
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:54187
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:62510
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0046325	negative regulation of glucose import	ISA	J:86301
Biological Process	GO:0007399	nervous system development	ISO	J:155856
Biological Process	GO:0050776	regulation of immune response	IMP	J:88527
Biological Process	GO:0019222	regulation of metabolic process	IMP	J:86301
Biological Process	GO:0046578	regulation of Ras protein signal transduction	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247