GO Annotations Graph

• Symbol: Pin1
• Name: peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1
• ID: MGI:1346036

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:186644
Molecular Function	GO:0016859	cis-trans isomerase activity	ISO	J:164563
Molecular Function	GO:0003774	cytoskeletal motor activity	IMP	J:186644
Molecular Function	GO:0032794	GTPase activating protein binding	ISO	J:164563
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	ISO	J:164563
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IDA	J:107132
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	ISO	J:164563
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IDA	J:304047
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IBA	J:265628
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IDA	J:128271
Molecular Function	GO:0051219	phosphoprotein binding	IPI	J:257324
Molecular Function	GO:0050815	phosphoserine residue binding	ISO	J:164563
Molecular Function	GO:0050816	phosphothreonine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:174543
Molecular Function	GO:0005515	protein binding	IPI	J:122511
Molecular Function	GO:0005515	protein binding	IPI	J:162391
Molecular Function	GO:0005515	protein binding	IPI	J:304047
Molecular Function	GO:0005515	protein binding	IPI	J:151773
Cellular Component	GO:0036064	ciliary basal body	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:186644
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326650
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:326650
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326650
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:326650
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326650
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326650
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:326650
Cellular Component	GO:0030496	midbody	ISO	J:73065
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:186644
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:304047
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0099524	postsynaptic cytosol	ISO	J:164563
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	IMP	J:107132
Biological Process	GO:2000146	negative regulation of cell motility	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0042177	negative regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030182	neuron differentiation	IMP	J:186644
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IC	J:186644
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	ISO	J:164563
Biological Process	GO:0000413	protein peptidyl-prolyl isomerization	IDA	J:304047
Biological Process	GO:0000413	protein peptidyl-prolyl isomerization	ISO	J:164563
Biological Process	GO:0000413	protein peptidyl-prolyl isomerization	IDA	J:107132
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	IMP	J:228562
Biological Process	GO:0050821	protein stabilization	IMP	J:186644
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:83663
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:83663
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:83663
Biological Process	GO:0032465	regulation of cytokinesis	IMP	J:151773
Biological Process	GO:0032465	regulation of cytokinesis	ISO	J:73065
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:1900180	regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0001932	regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IEP	J:326650
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:326650
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	EXP	J:326650
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IMP	J:326650
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:326650
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:326650
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:326650
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0050808	synapse organization	IMP	J:186644