GO Annotations Graph

• Symbol: Apc2
• Name: APC regulator of WNT signaling pathway 2
• ID: MGI:1346052

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	IBA	J:265628
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:73065
Molecular Function	GO:0045295	gamma-catenin binding	IBA	J:265628
Molecular Function	GO:0008017	microtubule binding	IBA	J:265628
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0030877	beta-catenin destruction complex	NAS	J:319997
Cellular Component	GO:0030877	beta-catenin destruction complex	IBA	J:265628
Cellular Component	GO:0016342	catenin complex	IBA	J:265628
Cellular Component	GO:0016342	catenin complex	ISO	J:73065
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005881	cytoplasmic microtubule	ISO	J:164563
Cellular Component	GO:0005881	cytoplasmic microtubule	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0031941	filamentous actin	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0045171	intercellular bridge	ISO	J:164563
Cellular Component	GO:0031258	lamellipodium membrane	ISO	J:164563
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Biological Process	GO:0090630	activation of GTPase activity	ISO	J:164563
Biological Process	GO:0001708	cell fate specification	IBA	J:265628
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0000226	microtubule cytoskeleton organization	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0007026	negative regulation of microtubule depolymerization	IBA	J:265628
Biological Process	GO:0007399	nervous system development	IBA	J:265628
Biological Process	GO:0007389	pattern specification process	IBA	J:265628
Biological Process	GO:0045732	positive regulation of protein catabolic process	IBA	J:265628
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	J:319997
Biological Process	GO:0045595	regulation of cell differentiation	IBA	J:265628