GO Annotations Graph

• Symbol: Twf2
• Name: twinfilin actin binding protein 2
• ID: MGI:1346078

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0003779	actin binding	IEA	J:72247
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0003785	actin monomer binding	IDA	J:85274
Molecular Function	GO:0003785	actin monomer binding	IDA	J:147473
Molecular Function	GO:0003785	actin monomer binding	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:56491
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA	J:85274
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:56491
Cellular Component	GO:0005884	actin filament	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:56491
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9659536
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9663360
Cellular Component	GO:0030175	filopodium	IDA	J:85274
Cellular Component	GO:0030426	growth cone	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	IDA	J:85274
Cellular Component	GO:0030016	myofibril	IDA	J:147473
Cellular Component	GO:0030016	myofibril	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:85274
Cellular Component	GO:0032420	stereocilium	IDA	J:175347
Biological Process	GO:0030042	actin filament depolymerization	IBA	J:265628
Biological Process	GO:0051016	barbed-end actin filament capping	IDA	J:147473
Biological Process	GO:0051016	barbed-end actin filament capping	IBA	J:265628
Biological Process	GO:0030030	cell projection organization	IEA	J:60000
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0071300	cellular response to retinoic acid	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:56491
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030837	negative regulation of actin filament polymerization	IDA	J:85274
Biological Process	GO:0045773	positive regulation of axon extension	ISO	J:164563
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	IBA	J:265628
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0010591	regulation of lamellipodium assembly	IBA	J:265628
Biological Process	GO:0032532	regulation of microvillus length	IC	J:175347
Biological Process	GO:0042989	sequestering of actin monomers	IDA	J:147473
Biological Process	GO:0042989	sequestering of actin monomers	IBA	J:265628