GO Annotations Graph

• Symbol: Aplnr
• Name: apelin receptor
• ID: MGI:1346086

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0060182	apelin receptor activity	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0007512	adult heart development	IMP	J:244834
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0035904	aorta development	IMP	J:213291
Biological Process	GO:0060183	apelin receptor signaling pathway	IMP	J:213291
Biological Process	GO:0003171	atrioventricular valve development	IMP	J:213291
Biological Process	GO:0001568	blood vessel development	IBA	J:265628
Biological Process	GO:0060976	coronary vasculature development	IMP	J:213291
Biological Process	GO:0060976	coronary vasculature development	IMP	J:245878
Biological Process	GO:0003272	endocardial cushion formation	IMP	J:213291
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007369	gastrulation	IEA	J:60000
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0001947	heart looping	IMP	J:213291
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	IBA	J:265628
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:213291
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP	J:245878
Biological Process	GO:0031065	positive regulation of histone deacetylation	IMP	J:213291
Biological Process	GO:1904325	positive regulation of inhibitory G protein-coupled receptor phosphorylation	ISO	J:164563
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0050878	regulation of body fluid levels	ISO	J:155856
Biological Process	GO:1903596	regulation of gap junction assembly	IMP	J:213291
Biological Process	GO:0010468	regulation of gene expression	IMP	J:213291
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0035886	vascular associated smooth muscle cell differentiation	IMP	J:213291
Biological Process	GO:0001944	vasculature development	IMP	J:213291
Biological Process	GO:0001570	vasculogenesis	IMP	J:244834
Biological Process	GO:0060841	venous blood vessel development	IMP	J:213291
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:213291