GO Annotations Graph

• Symbol: Map2k5
• Name: mitogen-activated protein kinase kinase 5
• ID: MGI:1346345

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004708	MAP kinase kinase activity	IBA	J:265628
Molecular Function	GO:0004708	MAP kinase kinase activity	IDA	J:153141
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:85661
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IDA	J:153141
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005819	spindle	IDA	J:93217
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:155856
Biological Process	GO:0070375	ERK5 cascade	ISO	J:155856
Biological Process	GO:0007507	heart development	IMP	J:95388
Biological Process	GO:0007507	heart development	IMP	J:95388
Biological Process	GO:0007507	heart development	IMP	J:95388
Biological Process	GO:0007507	heart development	IMP	J:95388
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:153141
Biological Process	GO:0000165	MAPK cascade	IBA	J:265628
Biological Process	GO:0000165	MAPK cascade	IMP	J:95388
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	ISO	J:155856
Biological Process	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production	ISO	J:155856
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:155856
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	ISO	J:155856
Biological Process	GO:0032717	negative regulation of interleukin-8 production	ISO	J:155856
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:0060761	negative regulation of response to cytokine stimulus	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:155856
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856