GO Annotations Graph

• Symbol: Mapk7
• Name: mitogen-activated protein kinase 7
• ID: MGI:1346347

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004707	MAP kinase activity	ISO	J:155856
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:175200
Molecular Function	GO:0005515	protein binding	IPI	J:203314
Molecular Function	GO:0004672	protein kinase activity	IDA	J:175200
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:136088
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:136088
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:136088
Cellular Component	GO:0016605	PML body	ISO	J:164563
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IMP	J:136088
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:0071499	cellular response to laminar fluid shear stress	ISO	J:164563
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:164563
Biological Process	GO:0070375	ERK5 cascade	ISO	J:155856
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0000165	MAPK cascade	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:107620
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	IMP	J:136088
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0060761	negative regulation of response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:136088
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:175200
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0045765	regulation of angiogenesis	IMP	J:80044