GO Annotations Graph

• Symbol: Esrra
• Name: estrogen related receptor, alpha
• ID: MGI:1346831

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:130865
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:130865
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:130865
Molecular Function	GO:0034056	estrogen response element binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0003707	nuclear steroid receptor activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:261824
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:130865
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0005496	steroid binding	IEA	J:72247
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0045171	intercellular bridge	ISO	J:164563
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:130865
Biological Process	GO:0051216	cartilage development	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:130865
Biological Process	GO:1900078	positive regulation of cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:167144
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:130865
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0030278	regulation of ossification	ISO	J:155856
Biological Process	GO:0045667	regulation of osteoblast differentiation	ISO	J:155856
Biological Process	GO:0045670	regulation of osteoclast differentiation	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628