GO Annotations Graph

• Symbol: Mapk1
• Name: mitogen-activated protein kinase 1
• ID: MGI:1346858

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:230602
Molecular Function	GO:0016301	kinase activity	IDA	J:83953
Molecular Function	GO:0016301	kinase activity	IDA	J:93976
Molecular Function	GO:0004707	MAP kinase activity	ISO	J:155856
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:3247
Molecular Function	GO:0004707	MAP kinase activity	ISO	J:327224
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:42368
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:92782
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:172165
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:79147
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:31951
Molecular Function	GO:0004707	MAP kinase activity	IMP	J:75391
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:35279
Molecular Function	GO:0004707	MAP kinase activity	IMP	J:172165
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:98599
Molecular Function	GO:0004708	MAP kinase kinase activity	IMP	J:228528
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0019902	phosphatase binding	IPI	J:31652
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0001784	phosphotyrosine residue binding	IMP	J:86622
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:200303
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:152628
Molecular Function	GO:0005515	protein binding	IPI	J:136810
Molecular Function	GO:0005515	protein binding	IPI	J:198938
Molecular Function	GO:0005515	protein binding	IPI	J:200340
Molecular Function	GO:0005515	protein binding	IPI	J:238455
Molecular Function	GO:0005515	protein binding	IPI	J:238455
Molecular Function	GO:0005515	protein binding	IPI	J:248467
Molecular Function	GO:0005515	protein binding	IPI	J:131448
Molecular Function	GO:0005515	protein binding	IPI	J:117798
Molecular Function	GO:0005515	protein binding	IPI	J:93997
Molecular Function	GO:0005515	protein binding	IPI	J:117524
Molecular Function	GO:0005515	protein binding	IPI	J:93976
Molecular Function	GO:0005515	protein binding	IPI	J:91443
Molecular Function	GO:0004672	protein kinase activity	IDA	J:88279
Molecular Function	GO:0004672	protein kinase activity	IDA	J:137572
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:332980
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:202592
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-198706
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-9769840
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:73065
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	IDA	J:154965
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005901	caveola	TAS	J:180564
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:238455
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:74534
Cellular Component	GO:0005737	cytoplasm	IDA	J:79147
Cellular Component	GO:0005737	cytoplasm	IDA	J:84750
Cellular Component	GO:0005856	cytoskeleton	TAS	J:180564
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	J:180564
Cellular Component	GO:0005829	cytosol	IDA	J:46223
Cellular Component	GO:0005829	cytosol	IDA	J:193006
Cellular Component	GO:0005829	cytosol	IDA	J:131696
Cellular Component	GO:0032839	dendrite cytoplasm	ISO	J:155856
Cellular Component	GO:0005769	early endosome	TAS	J:180564
Cellular Component	GO:0005925	focal adhesion	TAS	J:180564
Cellular Component	GO:0005794	Golgi apparatus	TAS	J:180564
Cellular Component	GO:0005770	late endosome	TAS	J:180564
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	TAS	J:180564
Cellular Component	GO:0005739	mitochondrion	IDA	J:131696
Cellular Component	GO:0005654	nucleoplasm	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-198706
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9769840
Cellular Component	GO:0005634	nucleus	IDA	J:238455
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	TAS	J:180564
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:74534
Cellular Component	GO:0005634	nucleus	IDA	J:102188
Cellular Component	GO:0005634	nucleus	IDA	J:84750
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0031143	pseudopodium	IDA	J:85273
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0030521	androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0009887	animal organ morphogenesis	IDA	J:72305
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0050853	B cell receptor signaling pathway	IDA	J:42368
Biological Process	GO:0060020	Bergmann glial cell differentiation	IGI	J:205567
Biological Process	GO:0061308	cardiac neural crest cell development involved in heart development	IGI	J:144862
Biological Process	GO:0072584	caveolin-mediated endocytosis	TAS	J:180564
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0007166	cell surface receptor signaling pathway	IBA	J:265628
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0071276	cellular response to cadmium ion	ISO	J:164563
Biological Process	GO:1903351	cellular response to dopamine	ISO	J:164563
Biological Process	GO:0071310	cellular response to organic substance	ISO	J:155856
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IGI	J:211147
Biological Process	GO:0019858	cytosine metabolic process	IDA	J:93976
Biological Process	GO:0046697	decidualization	ISO	J:155856
Biological Process	GO:0015966	diadenosine tetraphosphate biosynthetic process	ISO	J:155856
Biological Process	GO:0006974	DNA damage response	IDA	J:93432
Biological Process	GO:0006351	DNA-templated transcription	NAS	J:135485
Biological Process	GO:0038127	ERBB signaling pathway	ISO	J:164563
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IGI	J:143745
Biological Process	GO:0060324	face development	IGI	J:144862
Biological Process	GO:0060324	face development	IMP	J:144862
Biological Process	GO:0007507	heart development	IMP	J:144862
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:326639
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:209511
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:327218
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0060716	labyrinthine layer blood vessel development	IMP	J:89903
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:84896
Biological Process	GO:0060291	long-term synaptic potentiation	IGI	J:163089
Biological Process	GO:0060425	lung morphogenesis	IGI	J:214083
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IDA	J:145651
Biological Process	GO:0000165	MAPK cascade	ISO	J:155856
Biological Process	GO:0000165	MAPK cascade	IDA	J:31951
Biological Process	GO:0000165	MAPK cascade	IDA	J:42368
Biological Process	GO:0000165	MAPK cascade	IDA	J:35279
Biological Process	GO:0045596	negative regulation of cell differentiation	IGI	J:88964
Biological Process	GO:0014032	neural crest cell development	IGI	J:144862
Biological Process	GO:0042473	outer ear morphogenesis	IGI	J:144862
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:202592
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:172165
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:172165
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:73065
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IDA	J:202592
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	ISO	J:164563
Biological Process	GO:0120041	positive regulation of macrophage proliferation	ISO	J:164563
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:0051973	positive regulation of telomerase activity	ISO	J:164563
Biological Process	GO:1904355	positive regulation of telomere capping	ISO	J:164563
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	ISO	J:155856
Biological Process	GO:0050847	progesterone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:93976
Biological Process	GO:0006468	protein phosphorylation	IDA	J:137572
Biological Process	GO:0006468	protein phosphorylation	IDA	J:75391
Biological Process	GO:0006468	protein phosphorylation	IMP	J:98599
Biological Process	GO:0006468	protein phosphorylation	IDA	J:88279
Biological Process	GO:0030641	regulation of cellular pH	IMP	J:228528
Biological Process	GO:0051493	regulation of cytoskeleton organization	TAS	J:180564
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	NAS	J:135485
Biological Process	GO:2000641	regulation of early endosome to late endosome transport	TAS	J:180564
Biological Process	GO:0090170	regulation of Golgi inheritance	TAS	J:180564
Biological Process	GO:0030278	regulation of ossification	IGI	J:157951
Biological Process	GO:0032872	regulation of stress-activated MAPK cascade	TAS	J:180564
Biological Process	GO:0070849	response to epidermal growth factor	ISO	J:164563
Biological Process	GO:0043627	response to estrogen	ISO	J:155856
Biological Process	GO:0043330	response to exogenous dsRNA	IDA	J:84896
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:84896
Biological Process	GO:0035094	response to nicotine	IGI	J:239214
Biological Process	GO:0035094	response to nicotine	ISO	J:155856
Biological Process	GO:0009636	response to toxic substance	ISO	J:155856
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856
Biological Process	GO:0007165	signal transduction	ISO	J:155856
Biological Process	GO:0043401	steroid hormone mediated signaling pathway	ISO	J:164563
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0050852	T cell receptor signaling pathway	IDA	J:35279
Biological Process	GO:0048538	thymus development	IGI	J:144862
Biological Process	GO:0030878	thyroid gland development	IGI	J:144862
Biological Process	GO:0060440	trachea formation	IGI	J:214083