GO Annotations Graph

• Symbol: Mapk14
• Name: mitogen-activated protein kinase 14
• ID: MGI:1346865

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IDA	J:97560
Molecular Function	GO:0016301	kinase activity	IDA	J:83953
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:46351
Molecular Function	GO:0004707	MAP kinase activity	ISO	J:155856
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:180479
Molecular Function	GO:0004707	MAP kinase activity	ISO	J:164563
Molecular Function	GO:0004707	MAP kinase activity	IMP	J:163789
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:148987
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:72242
Molecular Function	GO:0048273	mitogen-activated protein kinase p38 binding	ISO	J:164563
Molecular Function	GO:0051525	NFAT protein binding	IPI	J:180479
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:148784
Molecular Function	GO:0005515	protein binding	IPI	J:306595
Molecular Function	GO:0005515	protein binding	IPI	J:139340
Molecular Function	GO:0005515	protein binding	IPI	J:234156
Molecular Function	GO:0005515	protein binding	IPI	J:76596
Molecular Function	GO:0005515	protein binding	IPI	J:233586
Molecular Function	GO:0005515	protein binding	IPI	J:248273
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:158573
Molecular Function	GO:0005515	protein binding	IPI	J:158573
Molecular Function	GO:0004672	protein kinase activity	IDA	J:63425
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	EXP	J:168204
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-1605464
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:136088
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:180479
Cellular Component	GO:0005737	cytoplasm	IDA	J:113867
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-448953
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-448960
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-448961
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-451204
Cellular Component	GO:0005829	cytosol	IDA	J:299317
Cellular Component	GO:0005829	cytosol	IDA	J:131696
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:263465
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263465
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:263465
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263465
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263465
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263465
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:263465
Cellular Component	GO:0005739	mitochondrion	IDA	J:131696
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-1605464
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:180479
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:113867
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0000922	spindle pole	IDA	J:93217
Biological Process	GO:0001525	angiogenesis	IMP	J:73417
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0060348	bone development	IMP	J:163789
Biological Process	GO:0001502	cartilage condensation	IMP	J:196353
Biological Process	GO:0000902	cell morphogenesis	IGI	J:128355
Biological Process	GO:0071479	cellular response to ionizing radiation	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:205449
Biological Process	GO:0071223	cellular response to lipoteichoic acid	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IDA	J:211147
Biological Process	GO:0071493	cellular response to UV-B	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0002062	chondrocyte differentiation	IMP	J:196353
Biological Process	GO:0002062	chondrocyte differentiation	IDA	J:125386
Biological Process	GO:0000077	DNA damage checkpoint signaling	IMP	J:86382
Biological Process	GO:0006974	DNA damage response	IDA	J:158685
Biological Process	GO:0019395	fatty acid oxidation	IMP	J:90488
Biological Process	GO:0046323	glucose import	IMP	J:176538
Biological Process	GO:0006006	glucose metabolic process	IMP	J:90488
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:46351
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:84896
Biological Process	GO:0000165	MAPK cascade	IMP	J:163789
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IMP	J:196353
Biological Process	GO:0035331	negative regulation of hippo signaling	ISO	J:164563
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:163789
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:180479
Biological Process	GO:0038066	p38MAPK cascade	IDA	J:203388
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:180479
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:136088
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0001890	placenta development	IMP	J:176023
Biological Process	GO:0090336	positive regulation of brown fat cell differentiation	IMP	J:204430
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	IGI	J:176023
Biological Process	GO:0031281	positive regulation of cyclase activity	ISO	J:164563
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	ISO	J:164563
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	IMP	J:63425
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:202649
Biological Process	GO:0046326	positive regulation of glucose import	IMP	J:176538
Biological Process	GO:0032735	positive regulation of interleukin-12 production	ISO	J:164563
Biological Process	GO:0045663	positive regulation of myoblast differentiation	IMP	J:203388
Biological Process	GO:1901741	positive regulation of myoblast fusion	IMP	J:203388
Biological Process	GO:0010831	positive regulation of myotube differentiation	IMP	J:203388
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IMP	J:113750
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:63425
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IMP	J:100823
Biological Process	GO:0006468	protein phosphorylation	IDA	J:97560
Biological Process	GO:0006468	protein phosphorylation	IDA	J:100823
Biological Process	GO:1900015	regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:158685
Biological Process	GO:0030278	regulation of ossification	IDA	J:157951
Biological Process	GO:0099179	regulation of synaptic membrane adhesion	IDA	J:263465
Biological Process	GO:0099179	regulation of synaptic membrane adhesion	IMP	J:263465
Biological Process	GO:0099179	regulation of synaptic membrane adhesion	IEP	J:263465
Biological Process	GO:0099179	regulation of synaptic membrane adhesion	IDA	J:263465
Biological Process	GO:0099179	regulation of synaptic membrane adhesion	IDA	J:263465
Biological Process	GO:0099179	regulation of synaptic membrane adhesion	EXP	J:263465
Biological Process	GO:0099179	regulation of synaptic membrane adhesion	IDA	J:263465
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:203388
Biological Process	GO:0002021	response to dietary excess	IMP	J:156376
Biological Process	GO:0032868	response to insulin	IMP	J:156376
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:84896
Biological Process	GO:0032495	response to muramyl dipeptide	IDA	J:96035
Biological Process	GO:0035994	response to muscle stretch	IMP	J:176538
Biological Process	GO:0042770	signal transduction in response to DNA damage	ISO	J:164563
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:99323
Biological Process	GO:0048863	stem cell differentiation	IDA	J:125386
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:155856
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	ISO	J:164563
Biological Process	GO:0090400	stress-induced premature senescence	ISO	J:164563
Biological Process	GO:0051146	striated muscle cell differentiation	IGI	J:158573
Biological Process	GO:0051146	striated muscle cell differentiation	IGI	J:158573
Biological Process	GO:0051146	striated muscle cell differentiation	IGI	J:158573
Biological Process	GO:0051146	striated muscle cell differentiation	IGI	J:158573
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:63425
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IGI	J:141606
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IGI	J:141606
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IGI	J:141606
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:156376
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	ISO	J:164563