GO Annotations Graph

• Symbol: Map2k4
• Name: mitogen-activated protein kinase kinase 4
• ID: MGI:1346869

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0008545	JUN kinase kinase activity	ISO	J:155856
Molecular Function	GO:0008545	JUN kinase kinase activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004708	MAP kinase kinase activity	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:64817
Molecular Function	GO:0005515	protein binding	IPI	J:64817
Molecular Function	GO:0005515	protein binding	IPI	J:114128
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-209329
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-3299417
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-451681
Cellular Component	GO:0032839	dendrite cytoplasm	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:0007254	JNK cascade	ISO	J:155856
Biological Process	GO:0007254	JNK cascade	ISO	J:137475
Biological Process	GO:0000165	MAPK cascade	IBA	J:265628
Biological Process	GO:0000165	MAPK cascade	IPI	J:84524
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	IMP	J:215576
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:155856
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:155856
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:137475
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	IDA	J:231249
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0009611	response to wounding	IMP	J:215576