GO Annotations Graph

• Symbol: Map2k6
• Name: mitogen-activated protein kinase kinase 6
• ID: MGI:1346870

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004708	MAP kinase kinase activity	ISO	J:155856
Molecular Function	GO:0004708	MAP kinase kinase activity	ISO	J:164563
Molecular Function	GO:0004708	MAP kinase kinase activity	TAS	Reactome:R-MMU-448961
Molecular Function	GO:0004708	MAP kinase kinase activity	IBA	J:265628
Molecular Function	GO:0004708	MAP kinase kinase activity	IMP	J:163789
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:84524
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-448961
Cellular Component	GO:0005829	cytosol	ISO	J:302013
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0060348	bone development	IMP	J:163789
Biological Process	GO:0060048	cardiac muscle contraction	IMP	J:72242
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	IBA	J:265628
Biological Process	GO:0000165	MAPK cascade	IMP	J:163789
Biological Process	GO:0000165	MAPK cascade	IPI	J:84524
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:249909
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:163789
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IDA	J:88279
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:97560
Biological Process	GO:0043410	positive regulation of MAPK cascade	IGI	J:97560
Biological Process	GO:0043410	positive regulation of MAPK cascade	IGI	J:97560
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:72242
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	ISO	J:155856
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:88279
Biological Process	GO:0006468	protein phosphorylation	IDA	J:79231
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	ISO	J:164563