GO Annotations Graph

• Symbol: Map2k7
• Name: mitogen-activated protein kinase kinase 7
• ID: MGI:1346871

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0008545	JUN kinase kinase activity	ISO	J:155856
Molecular Function	GO:0008545	JUN kinase kinase activity	IDA	J:77617
Molecular Function	GO:0008545	JUN kinase kinase activity	IDA	J:44734
Molecular Function	GO:0008545	JUN kinase kinase activity	IBA	J:265628
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:155856
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:44734
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0004707	MAP kinase activity	IDA	J:44734
Molecular Function	GO:0004708	MAP kinase kinase activity	ISO	J:155856
Molecular Function	GO:0004708	MAP kinase kinase activity	ISO	J:164563
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	ISO	J:155856
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:97560
Molecular Function	GO:0005515	protein binding	IPI	J:77441
Molecular Function	GO:0005515	protein binding	IPI	J:77617
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	IPI	J:77617
Cellular Component	GO:0005737	cytoplasm	IDA	J:52243
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:52243
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Biological Process	GO:0071347	cellular response to interleukin-1	IMP	J:44734
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:44734
Biological Process	GO:0071470	cellular response to osmotic stress	ISO	J:155856
Biological Process	GO:0007254	JNK cascade	ISO	J:155856
Biological Process	GO:0007254	JNK cascade	IDA	J:77617
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:155856
Biological Process	GO:0046330	positive regulation of JNK cascade	IDA	J:44734
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IDA	J:77617
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0051973	positive regulation of telomerase activity	ISO	J:164563
Biological Process	GO:1904355	positive regulation of telomere capping	ISO	J:164563
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:2000671	regulation of motor neuron apoptotic process	IMP	J:215576
Biological Process	GO:0009408	response to heat	ISO	J:164563
Biological Process	GO:0006970	response to osmotic stress	ISO	J:164563
Biological Process	GO:0006970	response to osmotic stress	ISO	J:155856
Biological Process	GO:0034612	response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0009411	response to UV	ISO	J:164563
Biological Process	GO:0009611	response to wounding	IMP	J:215576
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:155856
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:0051403	stress-activated MAPK cascade	IBA	J:265628