GO Annotations Graph

• Symbol: Map3k1
• Name: mitogen-activated protein kinase kinase kinase 1
• ID: MGI:1346872

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0008092	cytoskeletal protein binding	IDA	J:216505
Molecular Function	GO:0008432	JUN kinase binding	ISO	J:155856
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	ISO	J:155856
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	IDA	J:88294
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004708	MAP kinase kinase activity	EXP	J:231211
Molecular Function	GO:0004708	MAP kinase kinase activity	EXP	J:231212
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	ISO	J:155856
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:114128
Molecular Function	GO:0005515	protein binding	IPI	J:64817
Molecular Function	GO:0005515	protein binding	IPI	J:64817
Molecular Function	GO:0005515	protein binding	IPI	J:215973
Molecular Function	GO:0005515	protein binding	IPI	J:137475
Molecular Function	GO:0005515	protein binding	IPI	J:85668
Molecular Function	GO:0004672	protein kinase activity	ISO	J:89527
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0046625	sphingolipid binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0030054	cell junction	ISO	J:73065
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2730880
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-933534
Cellular Component	GO:0031941	filamentous actin	IDA	J:216505
Cellular Component	GO:0016020	membrane	ISO	J:155856
Biological Process	GO:0008637	apoptotic mitochondrial changes	IMP	J:98322
Biological Process	GO:0043010	camera-type eye development	IMP	J:85346
Biological Process	GO:0003382	epithelial cell morphogenesis	IMP	J:193107
Biological Process	GO:0061029	eyelid development in camera-type eye	IMP	J:193107
Biological Process	GO:0061029	eyelid development in camera-type eye	IMP	J:216505
Biological Process	GO:0007254	JNK cascade	IDA	J:88294
Biological Process	GO:0000165	MAPK cascade	ISO	J:155856
Biological Process	GO:0002011	morphogenesis of an epithelial sheet	IMP	J:216505
Biological Process	GO:0032232	negative regulation of actin filament bundle assembly	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IMP	J:85346
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IMP	J:216505
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:155856
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IDA	J:64817
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:155856
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0050434	positive regulation of viral transcription	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:155856
Biological Process	GO:0030334	regulation of cell migration	IMP	J:85346
Biological Process	GO:0006970	response to osmotic stress	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:85346
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:155856
Biological Process	GO:0042060	wound healing	IMP	J:85346