GO Annotations Graph

• Symbol: Map3k4
• Name: mitogen-activated protein kinase kinase kinase 4
• ID: MGI:1346875

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:163137
Molecular Function	GO:0005515	protein binding	IPI	J:85664
Molecular Function	GO:0005515	protein binding	IPI	J:137475
Molecular Function	GO:0004672	protein kinase activity	IDA	J:163137
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:163137
Biological Process	GO:0060718	chorionic trophoblast cell differentiation	IMP	J:148987
Biological Process	GO:0048263	determination of dorsal identity	ISO	J:137475
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:163137
Biological Process	GO:0019100	male germ-line sex determination	IMP	J:7073
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0001890	placenta development	IMP	J:148987
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IDA	J:163137
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IMP	J:85664
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:0051973	positive regulation of telomerase activity	ISO	J:164563
Biological Process	GO:1904355	positive regulation of telomere capping	ISO	J:164563
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	IMP	J:148987
Biological Process	GO:0010225	response to UV-C	ISO	J:164563