GO Annotations Graph

• Symbol: Map3k5
• Name: mitogen-activated protein kinase kinase kinase 5
• ID: MGI:1346876

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	IDA	J:143783
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	ISO	J:164563
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	ISO	J:155856
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:109068
Molecular Function	GO:0005515	protein binding	IPI	J:273504
Molecular Function	GO:0005515	protein binding	IPI	J:143783
Molecular Function	GO:0005515	protein binding	IPI	J:97560
Molecular Function	GO:0005515	protein binding	IPI	J:151342
Molecular Function	GO:0005515	protein binding	IPI	J:97560
Molecular Function	GO:0005515	protein binding	IPI	J:77617
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IPI	J:143783
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:1990604	IRE1-TRAF2-ASK1 complex	ISO	J:164563
Cellular Component	GO:1902911	protein kinase complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:1902170	cellular response to reactive nitrogen species	IMP	J:146389
Biological Process	GO:0033554	cellular response to stress	IBA	J:265628
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:218004
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	ISO	J:164563
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IBA	J:265628
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IDA	J:143783
Biological Process	GO:0007254	JNK cascade	ISO	J:155856
Biological Process	GO:0007254	JNK cascade	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	ISO	J:164563
Biological Process	GO:0038066	p38MAPK cascade	IEP	J:184291
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	IDA	J:143783
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:218004
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:97560
Biological Process	GO:0045663	positive regulation of myoblast differentiation	IDA	J:184291
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	IMP	J:218004
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	ISO	J:155856
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0097300	programmed necrotic cell death	IMP	J:146389
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0043067	regulation of programmed cell death	IGI	J:151342
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IMP	J:218004
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:164563