GO Annotations Graph

• Symbol: Map3k12
• Name: mitogen-activated protein kinase kinase kinase 12
• ID: MGI:1346881

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	IEA	J:72245
Molecular Function	GO:0004709	MAP kinase kinase kinase activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:113678
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IMP	J:236918
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:236918
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:113678
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:20630
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	IDA	J:132726
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:113678
Cellular Component	GO:0030426	growth cone	IDA	J:132726
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:113678
Biological Process	GO:0007254	JNK cascade	IMP	J:236918
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	IMP	J:215576
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:236918
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:20630
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IDA	J:20630
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IMP	J:236918
Biological Process	GO:0045860	positive regulation of protein kinase activity	IMP	J:236918
Biological Process	GO:0043687	post-translational protein modification	IDA	J:113678
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:113678
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:20630
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563