GO Annotations Graph

• Symbol: Map4k1
• Name: mitogen-activated protein kinase kinase kinase kinase 1
• ID: MGI:1346882

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IDA	J:37543
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0008349	MAP kinase kinase kinase kinase activity	ISO	J:164563
Molecular Function	GO:0008349	MAP kinase kinase kinase kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:248224
Molecular Function	GO:0005515	protein binding	IPI	J:37543
Molecular Function	GO:0005515	protein binding	IPI	J:91552
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:37543
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	ISO	J:164563
Biological Process	GO:1904628	cellular response to phorbol 13-acetate 12-myristate	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:37543
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0007254	JNK cascade	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:37543
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628