GO Annotations Graph

• Symbol: Med21
• Name: mediator complex subunit 21
• ID: MGI:1347064

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:103507
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:73065
Molecular Function	GO:0003712	transcription coregulator activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:155856
Cellular Component	GO:0070847	core mediator complex	ISO	J:164563
Cellular Component	GO:0016592	mediator complex	IBA	J:265628
Cellular Component	GO:0016592	mediator complex	IDA	J:92973
Cellular Component	GO:0016592	mediator complex	ISO	J:73065
Cellular Component	GO:0016592	mediator complex	IDA	J:77765
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-556760
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0000151	ubiquitin ligase complex	ISO	J:155856
Biological Process	GO:0001824	blastocyst development	IMP	J:57760
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	NAS	J:320035
Biological Process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	NAS	J:320035
Biological Process	GO:0016567	protein ubiquitination	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0051123	RNA polymerase II preinitiation complex assembly	NAS	J:320035
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:164442
Biological Process	GO:0006366	transcription by RNA polymerase II	IC	J:77765