GO Annotations Graph

• Symbol: Axl
• Name: AXL receptor tyrosine kinase
• ID: MGI:1347244

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0032036	myosin heavy chain binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:155856
Molecular Function	GO:0001786	phosphatidylserine binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:141251
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0001618	virus receptor activity	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0043277	apoptotic cell clearance	IGI	J:200704
Biological Process	GO:0043277	apoptotic cell clearance	IGI	J:133455
Biological Process	GO:0043277	apoptotic cell clearance	IGI	J:133455
Biological Process	GO:0043277	apoptotic cell clearance	IGI	J:145835
Biological Process	GO:0043277	apoptotic cell clearance	IMP	J:147638
Biological Process	GO:0006915	apoptotic process	IMP	J:122626
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:122626
Biological Process	GO:0030154	cell differentiation	ISO	J:155856
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0031668	cellular response to extracellular stimulus	IDA	J:54434
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0035457	cellular response to interferon-alpha	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	IGI	J:44193
Biological Process	GO:0034101	erythrocyte homeostasis	IMP	J:131177
Biological Process	GO:0034101	erythrocyte homeostasis	IGI	J:131177
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:157130
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:95952
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:157130
Biological Process	GO:0021885	forebrain cell migration	IGI	J:141251
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IMP	J:122626
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0046649	lymphocyte activation	IGI	J:70420
Biological Process	GO:0046649	lymphocyte activation	IGI	J:70420
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:124396
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0001779	natural killer cell differentiation	IBA	J:265628
Biological Process	GO:0001779	natural killer cell differentiation	IGI	J:112666
Biological Process	GO:0001779	natural killer cell differentiation	IGI	J:112666
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:182390
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:122626
Biological Process	GO:0043066	negative regulation of apoptotic process	IGI	J:44193
Biological Process	GO:0001818	negative regulation of cytokine production	IGI	J:200704
Biological Process	GO:2000669	negative regulation of dendritic cell apoptotic process	ISO	J:164563
Biological Process	GO:0051250	negative regulation of lymphocyte activation	IGI	J:70420
Biological Process	GO:0051250	negative regulation of lymphocyte activation	IGI	J:70420
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	IGI	J:124396
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:141251
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IGI	J:141251
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IGI	J:124396
Biological Process	GO:0032689	negative regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IBA	J:265628
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:141251
Biological Process	GO:0001764	neuron migration	IMP	J:157278
Biological Process	GO:0001764	neuron migration	IGI	J:141251
Biological Process	GO:0001764	neuron migration	IGI	J:141251
Biological Process	GO:0097350	neutrophil clearance	IGI	J:200704
Biological Process	GO:0042698	ovulation cycle	IGI	J:141251
Biological Process	GO:0006909	phagocytosis	ISO	J:164563
Biological Process	GO:0006909	phagocytosis	IBA	J:265628
Biological Process	GO:0006909	phagocytosis	IGI	J:157130
Biological Process	GO:0006909	phagocytosis	IGI	J:157130
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0030168	platelet activation	IBA	J:265628
Biological Process	GO:0030168	platelet activation	IMP	J:95952
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	ISO	J:164563
Biological Process	GO:0048549	positive regulation of pinocytosis	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IMP	J:182390
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IBA	J:265628
Biological Process	GO:1903902	positive regulation of viral life cycle	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:95952
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:122626
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0032940	secretion by cell	IMP	J:95952
Biological Process	GO:0007283	spermatogenesis	IGI	J:157130
Biological Process	GO:0007283	spermatogenesis	IGI	J:54681
Biological Process	GO:0007283	spermatogenesis	IGI	J:157130
Biological Process	GO:0007283	spermatogenesis	IGI	J:54681
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	IMP	J:95952
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0032640	tumor necrosis factor production	IGI	J:124396
Biological Process	GO:0060068	vagina development	IGI	J:142166
Biological Process	GO:0060068	vagina development	IGI	J:142166
Biological Process	GO:0046718	viral entry into host cell	ISO	J:164563