GO Annotations Graph

• Symbol: Ccl21b
• Name: C-C motif chemokine ligand 21B (leucine)
• ID: MGI:1349182

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048020	CCR chemokine receptor binding	IBA	J:265628
Molecular Function	GO:0008009	chemokine activity	ISO	J:164563
Molecular Function	GO:0008009	chemokine activity	IBA	J:265628
Molecular Function	GO:0008009	chemokine activity	ISO	J:42623
Molecular Function	GO:0042379	chemokine receptor binding	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141392
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0090630	activation of GTPase activity	ISO	J:164563
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0060326	cell chemotaxis	ISO	J:42623
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0071347	cellular response to interleukin-1	IBA	J:265628
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IBA	J:265628
Biological Process	GO:0071346	cellular response to type II interferon	IBA	J:265628
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0002407	dendritic cell chemotaxis	ISO	J:164563
Biological Process	GO:0001768	establishment of T cell polarity	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0031640	killing of cells of another organism	ISO	J:164563
Biological Process	GO:0030595	leukocyte chemotaxis	ISO	J:42623
Biological Process	GO:0048247	lymphocyte chemotaxis	IBA	J:265628
Biological Process	GO:0035759	mesangial cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0002548	monocyte chemotaxis	IBA	J:265628
Biological Process	GO:2000669	negative regulation of dendritic cell apoptotic process	ISO	J:164563
Biological Process	GO:1903237	negative regulation of leukocyte tethering or rolling	ISO	J:164563
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	ISO	J:42623
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:2000147	positive regulation of cell motility	ISO	J:164563
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0051491	positive regulation of filopodium assembly	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:2000529	positive regulation of myeloid dendritic cell chemotaxis	ISO	J:164563
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISO	J:164563
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0031274	positive regulation of pseudopodium assembly	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0034695	response to prostaglandin E	ISO	J:164563
Biological Process	GO:0031529	ruffle organization	ISO	J:164563
Biological Process	GO:0007165	signal transduction	ISO	J:42623