Ccl21a GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Ccl21a
C-C motif chemokine ligand 21 (serine)
MGI:1349183

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048020	CCR chemokine receptor binding	IBA	J:265628
Molecular Function	GO:0031732	CCR7 chemokine receptor binding	IPI	J:233944
Molecular Function	GO:0008009	chemokine activity	IMP	J:259583
Molecular Function	GO:0008009	chemokine activity	IDA	J:175209
Molecular Function	GO:0008009	chemokine activity	ISO	J:164563
Molecular Function	GO:0008009	chemokine activity	IBA	J:265628
Molecular Function	GO:0042379	chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0090630	activation of GTPase activity	ISO	J:164563
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0048469	cell maturation	IDA	J:97971
Biological Process	GO:1990869	cellular response to chemokine	IMP	J:259583
Biological Process	GO:0071347	cellular response to interleukin-1	IBA	J:265628
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IBA	J:265628
Biological Process	GO:0071346	cellular response to type II interferon	IBA	J:265628
Biological Process	GO:0038116	chemokine (C-C motif) ligand 21 signaling pathway	IMP	J:259583
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0002407	dendritic cell chemotaxis	IDA	J:175209
Biological Process	GO:0002407	dendritic cell chemotaxis	ISO	J:164563
Biological Process	GO:0097026	dendritic cell dendrite assembly	IDA	J:175209
Biological Process	GO:0001768	establishment of T cell polarity	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0001771	immunological synapse formation	IDA	J:97971
Biological Process	GO:0050930	induction of positive chemotaxis	IDA	J:44265
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0031640	killing of cells of another organism	ISO	J:164563
Biological Process	GO:0048535	lymph node development	IMP	J:83288
Biological Process	GO:0048247	lymphocyte chemotaxis	IBA	J:265628
Biological Process	GO:0035759	mesangial cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0002548	monocyte chemotaxis	IBA	J:265628
Biological Process	GO:2000669	negative regulation of dendritic cell apoptotic process	ISO	J:164563
Biological Process	GO:2000548	negative regulation of dendritic cell dendrite assembly	IDA	J:175209
Biological Process	GO:1903237	negative regulation of leukocyte tethering or rolling	ISO	J:164563
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:2000147	positive regulation of cell motility	ISO	J:164563
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0050921	positive regulation of chemotaxis	IDA	J:233944
Biological Process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	IDA	J:97971
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0051491	positive regulation of filopodium assembly	ISO	J:164563
Biological Process	GO:0010560	positive regulation of glycoprotein biosynthetic process	IDA	J:97971
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	NAS	J:175337
Biological Process	GO:2000529	positive regulation of myeloid dendritic cell chemotaxis	ISO	J:164563
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISO	J:164563
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0031274	positive regulation of pseudopodium assembly	ISO	J:164563
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	IDA	J:84270
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	IMP	J:259583
Biological Process	GO:2000406	positive regulation of T cell migration	ISO	J:200103
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0034695	response to prostaglandin E	ISO	J:164563
Biological Process	GO:0031529	ruffle organization	ISO	J:164563
Biological Process	GO:0031295	T cell costimulation	IDA	J:97971

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24