GO Annotations Graph

• Symbol: Pclo
• Name: piccolo (presynaptic cytomatrix protein)
• ID: MGI:1349390

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0005522	profilin binding	IDA	J:57915
Molecular Function	GO:0005515	protein binding	IPI	J:153882
Molecular Function	GO:0005515	protein binding	IPI	J:153882
Molecular Function	GO:0005515	protein binding	IPI	J:81000
Molecular Function	GO:0005515	protein binding	IPI	J:153882
Molecular Function	GO:0005515	protein binding	IPI	J:153882
Molecular Function	GO:0005515	protein binding	IPI	J:81000
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	IBA	J:265628
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	IMP	J:263436
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	IPI	J:263436
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	IDA	J:263436
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	IDA	J:263436
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	IMP	J:263436
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	IDA	J:263436
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	IMP	J:263436
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	IDA	J:263436
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0044316	cone cell pedicle	ISO	J:155856
Cellular Component	GO:0048788	cytoskeleton of presynaptic active zone	ISO	J:155856
Cellular Component	GO:0048788	cytoskeleton of presynaptic active zone	IBA	J:265628
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IBA	J:265628
Cellular Component	GO:0005798	Golgi-associated vesicle	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0060077	inhibitory synapse	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0048786	presynaptic active zone	ISO	J:155856
Cellular Component	GO:0098831	presynaptic active zone cytoplasmic component	ISO	J:155856
Cellular Component	GO:0098831	presynaptic active zone cytoplasmic component	IDA	J:237681
Cellular Component	GO:0097470	ribbon synapse	ISO	J:155856
Cellular Component	GO:0044317	rod spherule	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:57915
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:153882
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:155856
Cellular Component	GO:0030133	transport vesicle	ISO	J:155856
Biological Process	GO:0007010	cytoskeleton organization	IDA	J:57915
Biological Process	GO:0030073	insulin secretion	IDA	J:81000
Biological Process	GO:0098815	modulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:1903423	positive regulation of synaptic vesicle recycling	ISO	J:155856
Biological Process	GO:0099526	presynapse to nucleus signaling pathway	IMP	J:220712
Biological Process	GO:1904071	presynaptic active zone assembly	ISO	J:155856
Biological Process	GO:1904071	presynaptic active zone assembly	IBA	J:265628
Biological Process	GO:0035418	protein localization to synapse	IGI	J:220712
Biological Process	GO:0035418	protein localization to synapse	IBA	J:265628
Biological Process	GO:0051036	regulation of endosome size	ISO	J:155856
Biological Process	GO:0017157	regulation of exocytosis	IDA	J:81000
Biological Process	GO:1904666	regulation of ubiquitin protein ligase activity	ISO	J:155856
Biological Process	GO:0007416	synapse assembly	IEA	J:72247
Biological Process	GO:0050808	synapse organization	ISO	J:155856
Biological Process	GO:0097091	synaptic vesicle clustering	IMP	J:159311
Biological Process	GO:0097091	synaptic vesicle clustering	IDA	J:159311
Biological Process	GO:0097091	synaptic vesicle clustering	IDA	J:159311
Biological Process	GO:0016080	synaptic vesicle targeting	NAS	J:57915