GO Annotations Graph

• Symbol: Cops5
• Name: COP9 signalosome subunit 5
• ID: MGI:1349415

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019784	deNEDDylase activity	IBA	J:265628
Molecular Function	GO:0019899	enzyme binding	IPI	J:175599
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0035718	macrophage migration inhibitory factor binding	IPI	J:175599
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140492	metal-dependent deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	IEA	J:72247
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	IBA	J:265628
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:50270
Molecular Function	GO:0005515	protein binding	IPI	J:285722
Molecular Function	GO:0005515	protein binding	IPI	J:50270
Molecular Function	GO:0005515	protein binding	IPI	J:50270
Molecular Function	GO:0005515	protein binding	IPI	J:50270
Molecular Function	GO:0005515	protein binding	IPI	J:50270
Molecular Function	GO:0005515	protein binding	IPI	J:50270
Molecular Function	GO:0003713	transcription coactivator activity	TAS	J:50270
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0008180	COP9 signalosome	ISO	J:164563
Cellular Component	GO:0008180	COP9 signalosome	IBA	J:265628
Cellular Component	GO:0008180	COP9 signalosome	IDA	J:50270
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	TAS	J:50270
Biological Process	GO:1990182	exosomal secretion	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000338	protein deneddylation	ISO	J:164563
Biological Process	GO:0000338	protein deneddylation	IBA	J:265628
Biological Process	GO:0016579	protein deubiquitination	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0051726	regulation of cell cycle	IMP	J:93979
Biological Process	GO:0006355	regulation of DNA-templated transcription	TAS	J:50270
Biological Process	GO:1903894	regulation of IRE1-mediated unfolded protein response	ISO	J:164563
Biological Process	GO:0046328	regulation of JNK cascade	ISO	J:164563