GO Annotations Graph

• Symbol: Aifm1
• Name: apoptosis-inducing factor, mitochondrion-associated 1
• ID: MGI:1349419

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:186001
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	TAS	J:63402
Molecular Function	GO:0071949	FAD binding	IDA	J:186001
Molecular Function	GO:0071949	FAD binding	ISO	J:164563
Molecular Function	GO:0071949	FAD binding	IBA	J:265628
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	IEA	J:72247
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	ISO	J:164563
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	IDA	J:186001
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	IBA	J:265628
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	ISO	J:164563
Molecular Function	GO:0072572	poly-ADP-D-ribose binding	IDA	J:186001
Molecular Function	GO:0005515	protein binding	IPI	J:201385
Molecular Function	GO:0005515	protein binding	IPI	J:131590
Molecular Function	GO:0005515	protein binding	IPI	J:159292
Molecular Function	GO:0005515	protein binding	IPI	J:159292
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:87358
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:131590
Cellular Component	GO:0005829	cytosol	TAS	J:63402
Cellular Component	GO:0005829	cytosol	IDA	J:146172
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	IEA	J:60000
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:164563
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:164563
Cellular Component	GO:0005758	mitochondrial intermembrane space	TAS	J:63402
Cellular Component	GO:0005741	mitochondrial outer membrane	TAS	J:87334
Cellular Component	GO:0005739	mitochondrion	IDA	J:131590
Cellular Component	GO:0005739	mitochondrion	IMP	J:186001
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:159292
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:291285
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	IDA	J:177007
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:93333
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:146172
Cellular Component	GO:0005739	mitochondrion	IDA	J:105496
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:159292
Cellular Component	GO:0005634	nucleus	IDA	J:131590
Cellular Component	GO:0005634	nucleus	IDA	J:77719
Cellular Component	GO:0005634	nucleus	IMP	J:186001
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:202975
Cellular Component	GO:0005634	nucleus	IDA	J:105496
Cellular Component	GO:0005634	nucleus	IDA	J:87358
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0008637	apoptotic mitochondrial changes	TAS	J:63402
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IBA	J:265628
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:131590
Biological Process	GO:0033108	mitochondrial respiratory chain complex assembly	IMP	J:256078
Biological Process	GO:0033108	mitochondrial respiratory chain complex assembly	ISO	J:164563
Biological Process	GO:0033108	mitochondrial respiratory chain complex assembly	IBA	J:265628
Biological Process	GO:0032981	mitochondrial respiratory chain complex I assembly	ISO	J:164563
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:98103
Biological Process	GO:0030182	neuron differentiation	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	TAS	J:180458
Biological Process	GO:0060545	positive regulation of necroptotic process	IDA	J:77719
Biological Process	GO:0060545	positive regulation of necroptotic process	IDA	J:186001
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0045041	protein import into mitochondrial intermembrane space	ISO	J:164563
Biological Process	GO:0045041	protein import into mitochondrial intermembrane space	IMP	J:256078
Biological Process	GO:1902510	regulation of apoptotic DNA fragmentation	IGI	J:98103
Biological Process	GO:0006979	response to oxidative stress	TAS	J:180458