GO Annotations Graph

• Symbol: Sh2d1b1
• Name: SH2 domain containing 1B1
• ID: MGI:1349420

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001784	phosphotyrosine residue binding	IDA	J:51754
Molecular Function	GO:0005515	protein binding	IPI	J:145969
Molecular Function	GO:0005515	protein binding	IPI	J:106459
Molecular Function	GO:0005515	protein binding	IPI	J:106459
Molecular Function	GO:0005515	protein binding	IPI	J:106459
Molecular Function	GO:0005515	protein binding	IPI	J:106459
Molecular Function	GO:0005515	protein binding	IPI	J:110195
Molecular Function	GO:0005515	protein binding	IPI	J:106459
Molecular Function	GO:0005515	protein binding	IPI	J:106459
Molecular Function	GO:0035591	signaling adaptor activity	NAS	J:190280
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0002366	leukocyte activation involved in immune response	IDA	J:190280
Biological Process	GO:0002769	natural killer cell inhibitory signaling pathway	IMP	J:110195
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IGI	J:151768
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IMP	J:110195
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IGI	J:151768
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	IMP	J:110195
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	IMP	J:110195
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:110195
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:106459
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:110195
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:110195
Biological Process	GO:0045089	positive regulation of innate immune response	IDA	J:190280
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IGI	J:166054
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IGI	J:166054
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IGI	J:151768
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IGI	J:151768
Biological Process	GO:0002717	positive regulation of natural killer cell mediated immunity	IMP	J:166054
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:106459
Biological Process	GO:0009967	positive regulation of signal transduction	NAS	J:190280
Biological Process	GO:0032609	type II interferon production	IMP	J:110195