GO Annotations Graph

• Symbol: Nherf1
• Name: NHERF family PDZ scaffold protein 1
• ID: MGI:1349482

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	ISO	J:164563
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0017081	chloride channel regulator activity	ISO	J:164563
Molecular Function	GO:0050780	dopamine receptor binding	IDA	J:162594
Molecular Function	GO:0015185	gamma-aminobutyric acid transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0070851	growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:155856
Molecular Function	GO:0045159	myosin II binding	ISO	J:155856
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0019902	phosphatase binding	IPI	J:169887
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0019902	phosphatase binding	IPI	J:105981
Molecular Function	GO:0005515	protein binding	IPI	J:185780
Molecular Function	GO:0005515	protein binding	IPI	J:185780
Molecular Function	GO:0005515	protein binding	IPI	J:185780
Molecular Function	GO:0005515	protein binding	IPI	J:201262
Molecular Function	GO:0005515	protein binding	IPI	J:212101
Molecular Function	GO:0005515	protein binding	IPI	J:83891
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0043495	protein-membrane adaptor activity	IBA	J:265628
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0031799	type 2 metabotropic glutamate receptor binding	ISO	J:164563
Molecular Function	GO:0031800	type 3 metabotropic glutamate receptor binding	ISO	J:164563
Cellular Component	GO:0045177	apical part of cell	IDA	J:88943
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:285002
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:78606
Cellular Component	GO:0031526	brush border membrane	IDA	J:95282
Cellular Component	GO:0031526	brush border membrane	IDA	J:95282
Cellular Component	GO:0071944	cell periphery	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:185780
Cellular Component	GO:0016020	membrane	IDA	J:170137
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005902	microvillus	ISO	J:164563
Cellular Component	GO:0031528	microvillus membrane	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0098797	plasma membrane protein complex	ISO	J:155856
Cellular Component	GO:0097225	sperm midpiece	IDA	J:185780
Cellular Component	GO:0032420	stereocilium	IDA	J:212101
Cellular Component	GO:0032420	stereocilium	IDA	J:212101
Cellular Component	GO:0032426	stereocilium tip	IDA	J:212101
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:95282
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	IMP	J:162594
Biological Process	GO:0060088	auditory receptor cell stereocilium organization	IMP	J:212101
Biological Process	GO:0032782	bile acid secretion	IMP	J:164550
Biological Process	GO:0090660	cerebrospinal fluid circulation	IDA	J:244254
Biological Process	GO:0090660	cerebrospinal fluid circulation	IMP	J:285002
Biological Process	GO:0044782	cilium organization	IMP	J:285002
Biological Process	GO:0045198	establishment of epithelial cell apical/basal polarity	ISO	J:164563
Biological Process	GO:0051683	establishment of Golgi localization	ISO	J:164563
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:119442
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:119442
Biological Process	GO:0010761	fibroblast migration	IGI	J:105981
Biological Process	GO:0051939	gamma-aminobutyric acid import	ISO	J:155856
Biological Process	GO:0022612	gland morphogenesis	ISO	J:164563
Biological Process	GO:0034635	glutathione transport	IMP	J:164550
Biological Process	GO:0098739	import across plasma membrane	ISO	J:155856
Biological Process	GO:0030643	intracellular phosphate ion homeostasis	IMP	J:78606
Biological Process	GO:0045199	maintenance of epithelial cell apical/basal polarity	IMP	J:285002
Biological Process	GO:0045199	maintenance of epithelial cell apical/basal polarity	ISO	J:164563
Biological Process	GO:0030033	microvillus assembly	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:2000146	negative regulation of cell motility	IMP	J:105981
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010764	negative regulation of fibroblast migration	IGI	J:105981
Biological Process	GO:0045930	negative regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	IMP	J:105981
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	IGI	J:105981
Biological Process	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	IMP	J:169887
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:169887
Biological Process	GO:0010766	negative regulation of sodium ion transport	IMP	J:119442
Biological Process	GO:0010766	negative regulation of sodium ion transport	IMP	J:119442
Biological Process	GO:0032416	negative regulation of sodium:proton antiporter activity	IMP	J:119442
Biological Process	GO:0007097	nuclear migration	ISO	J:164563
Biological Process	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	IMP	J:162594
Biological Process	GO:0007009	plasma membrane organization	IMP	J:285002
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0034767	positive regulation of monoatomic ion transmembrane transport	ISO	J:155856
Biological Process	GO:0008104	protein localization	IMP	J:113637
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	IBA	J:265628
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0008361	regulation of cell size	ISO	J:164563
Biological Process	GO:0045859	regulation of protein kinase activity	IMP	J:169887
Biological Process	GO:1903402	regulation of renal phosphate excretion	IMP	J:113637
Biological Process	GO:1903402	regulation of renal phosphate excretion	IMP	J:115757
Biological Process	GO:0070293	renal absorption	IMP	J:119876
Biological Process	GO:0070293	renal absorption	IMP	J:78606
Biological Process	GO:0097291	renal phosphate ion absorption	ISO	J:164563
Biological Process	GO:0003096	renal sodium ion transport	IMP	J:119442
Biological Process	GO:0007605	sensory perception of sound	IMP	J:212101
Biological Process	GO:0006814	sodium ion transport	IMP	J:119442
Biological Process	GO:0006814	sodium ion transport	IMP	J:119442
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000