GO Annotations Graph

• Symbol: Cul1
• Name: cullin 1
• ID: MGI:1349658

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:245285
Molecular Function	GO:0005515	protein binding	IPI	J:111403
Molecular Function	GO:0005515	protein binding	IPI	J:82741
Molecular Function	GO:0005515	protein binding	IPI	J:111403
Molecular Function	GO:0005515	protein binding	IPI	J:149890
Molecular Function	GO:0005515	protein binding	IPI	J:149890
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IBA	J:265628
Molecular Function	GO:0160072	ubiquitin ligase complex scaffold activity	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IC	J:82741
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IBA	J:265628
Cellular Component	GO:0031461	cullin-RING ubiquitin ligase complex	ISO	J:73065
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008677
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008715
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008717
Cellular Component	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	IDA	J:163142
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	IDA	J:196293
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	IBA	J:265628
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	IDA	J:82741
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:57767
Biological Process	GO:0006915	apoptotic process	IMP	J:57767
Biological Process	GO:0008283	cell population proliferation	IMP	J:57767
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	IDA	J:259707
Biological Process	GO:0006513	protein monoubiquitination	IGI	J:172833
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	J:163142
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IC	J:82741