GO Annotations Graph

• Symbol: Grm2
• Name: glutamate receptor, metabotropic 2
• ID: MGI:1351339

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005246	calcium channel regulator activity	IDA	J:73174
Molecular Function	GO:0005246	calcium channel regulator activity	IDA	J:21416
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0001641	group II metabotropic glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0001641	group II metabotropic glutamate receptor activity	IBA	J:265628
Molecular Function	GO:0001641	group II metabotropic glutamate receptor activity	IDA	J:21416
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Cellular Component	GO:0097449	astrocyte projection	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:283385
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:283385
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:283385
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:283385
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043005	neuron projection	IDA	J:101575
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0035095	behavioral response to nicotine	ISO	J:155856
Biological Process	GO:0033554	cellular response to stress	IDA	J:256101
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0010467	gene expression	IMP	J:268650
Biological Process	GO:0014047	glutamate secretion	ISO	J:155856
Biological Process	GO:0090461	intracellular glutamate homeostasis	IGI	J:256101
Biological Process	GO:0060292	long-term synaptic depression	IMP	J:34606
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:283385
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:283385
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:283385
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	EXP	J:283385
Biological Process	GO:0014059	regulation of dopamine secretion	ISO	J:155856
Biological Process	GO:0014048	regulation of glutamate secretion	ISO	J:155856
Biological Process	GO:0051896	regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:2001023	regulation of response to drug	ISO	J:155856
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	IBA	J:265628
Biological Process	GO:0042220	response to cocaine	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000