GO Annotations Graph

• Symbol: Grm5
• Name: glutamate receptor, metabotropic 5
• ID: MGI:1351342

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031687	A2A adenosine receptor binding	ISO	J:155856
Molecular Function	GO:0001640	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	ISO	J:164563
Molecular Function	GO:0099530	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IMP	J:146136
Molecular Function	GO:0099530	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	IBA	J:265628
Molecular Function	GO:0008066	glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0008066	glutamate receptor activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IMP	J:200211
Molecular Function	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IBA	J:265628
Molecular Function	GO:0001639	PLC activating G protein-coupled glutamate receptor activity	TAS	J:41096
Molecular Function	GO:0005515	protein binding	IPI	J:322391
Molecular Function	GO:0005515	protein binding	IPI	J:201741
Molecular Function	GO:0005515	protein binding	IPI	J:200071
Molecular Function	GO:0005515	protein binding	IPI	J:78892
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:155856
Cellular Component	GO:0097449	astrocyte projection	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:78892
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IDA	J:184110
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:78892
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	IBA	J:265628
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:103903
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:103903
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	ISO	J:164563
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	IGI	J:201741
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:164563
Biological Process	GO:1904646	cellular response to amyloid-beta	IGI	J:201741
Biological Process	GO:0007268	chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0050890	cognition	ISO	J:164563
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007612	learning	IMP	J:41096
Biological Process	GO:0007611	learning or memory	IGI	J:201741
Biological Process	GO:0007626	locomotory behavior	IGI	J:102700
Biological Process	GO:0007626	locomotory behavior	IGI	J:102700
Biological Process	GO:0007626	locomotory behavior	IMP	J:102700
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:103903
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:103903
Biological Process	GO:0040013	negative regulation of locomotion	ISO	J:155856
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	ISO	J:155856
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	IGI	J:201741
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:1902938	regulation of intracellular calcium activated chloride channel activity	ISO	J:164563
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	IMP	J:112751
Biological Process	GO:0001932	regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	IBA	J:265628
Biological Process	GO:0006448	regulation of translational elongation	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0050808	synapse organization	IGI	J:201741
Biological Process	GO:0099553	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	ISO	J:155856
Biological Process	GO:0099553	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IBA	J:265628