GO Annotations Graph

• Symbol: Pdk4
• Name: pyruvate dehydrogenase kinase, isoenzyme 4
• ID: MGI:1351481

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	TAS	J:58666
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	ISO	J:164563
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	ISO	J:155856
Molecular Function	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:60000
Biological Process	GO:0071398	cellular response to fatty acid	ISO	J:164563
Biological Process	GO:0009267	cellular response to starvation	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IMP	J:115895
Biological Process	GO:0006006	glucose metabolic process	IEA	J:60000
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:156363
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:2000811	negative regulation of anoikis	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0072593	reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate	ISO	J:164563
Biological Process	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate	IMP	J:115895
Biological Process	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate	TAS	J:58666
Biological Process	GO:0045124	regulation of bone resorption	IMP	J:179789
Biological Process	GO:0010565	regulation of cellular ketone metabolic process	IMP	J:115895
Biological Process	GO:0042304	regulation of fatty acid biosynthetic process	IMP	J:156363
Biological Process	GO:0042304	regulation of fatty acid biosynthetic process	ISO	J:164563
Biological Process	GO:0046320	regulation of fatty acid oxidation	IMP	J:115895
Biological Process	GO:0010906	regulation of glucose metabolic process	ISO	J:164563
Biological Process	GO:0010906	regulation of glucose metabolic process	IMP	J:115895
Biological Process	GO:0010906	regulation of glucose metabolic process	IBA	J:265628
Biological Process	GO:0006885	regulation of pH	IMP	J:185475
Biological Process	GO:0042594	response to starvation	IMP	J:115895