GO Annotations Graph

• Symbol: Prmt5
• Name: protein arginine N-methyltransferase 5
• ID: MGI:1351645

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IMP	J:136087
Molecular Function	GO:0070888	E-box binding	IDA	J:192252
Molecular Function	GO:0008469	histone arginine N-methyltransferase activity	IBA	J:265628
Molecular Function	GO:0070612	histone H2AR3 methyltransferase activity	IDA	J:109626
Molecular Function	GO:0044020	histone H4R3 methyltransferase activity	IMP	J:192252
Molecular Function	GO:0044020	histone H4R3 methyltransferase activity	ISO	J:164563
Molecular Function	GO:0044020	histone H4R3 methyltransferase activity	IDA	J:109626
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008327	methyl-CpG binding	ISO	J:164563
Molecular Function	GO:0008168	methyltransferase activity	ISO	J:164563
Molecular Function	GO:0008168	methyltransferase activity	ISO	J:92481
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:192252
Molecular Function	GO:0005515	protein binding	IPI	J:192252
Molecular Function	GO:0005515	protein binding	IPI	J:156247
Molecular Function	GO:0005515	protein binding	IPI	J:222673
Molecular Function	GO:0005515	protein binding	IPI	J:196248
Molecular Function	GO:0005515	protein binding	IPI	J:165553
Molecular Function	GO:0005515	protein binding	IPI	J:109626
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:138740
Molecular Function	GO:0016274	protein-arginine N-methyltransferase activity	ISO	J:164563
Molecular Function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0043021	ribonucleoprotein complex binding	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	IMP	J:192252
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:222673
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:109626
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0035097	histone methyltransferase complex	ISO	J:164563
Cellular Component	GO:0035097	histone methyltransferase complex	IDA	J:222673
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:112036
Cellular Component	GO:0034709	methylosome	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:112036
Cellular Component	GO:0005634	nucleus	NAS	J:320168
Cellular Component	GO:0005634	nucleus	IDA	J:222673
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:109626
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:192252
Biological Process	GO:0006353	DNA-templated transcription termination	ISO	J:164563
Biological Process	GO:0042118	endothelial cell activation	ISO	J:164563
Biological Process	GO:0010467	gene expression	IDA	J:109626
Biological Process	GO:0090161	Golgi ribbon formation	ISO	J:164563
Biological Process	GO:0034969	histone arginine methylation	IBA	J:265628
Biological Process	GO:0043985	histone H4-R3 methylation	NAS	J:320270
Biological Process	GO:0032259	methylation	IEA	J:60000
Biological Process	GO:0045596	negative regulation of cell differentiation	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:136087
Biological Process	GO:0018216	peptidyl-arginine methylation	ISO	J:164563
Biological Process	GO:0035246	peptidyl-arginine N-methylation	ISO	J:164563
Biological Process	GO:0035246	peptidyl-arginine N-methylation	ISO	J:92481
Biological Process	GO:1904992	positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	NAS	J:320168
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	ISO	J:155856
Biological Process	GO:0006479	protein methylation	ISO	J:155856
Biological Process	GO:0044030	regulation of DNA methylation	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	IBA	J:265628
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0000387	spliceosomal snRNP assembly	ISO	J:164563
Biological Process	GO:0000387	spliceosomal snRNP assembly	NAS	J:320168