GO Annotations Graph

• Symbol: Cxcl10
• Name: C-X-C motif chemokine ligand 10
• ID: MGI:1352450

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042056	chemoattractant activity	ISO	J:164563
Molecular Function	GO:0008009	chemokine activity	ISO	J:164563
Molecular Function	GO:0008009	chemokine activity	ISO	J:155856
Molecular Function	GO:0008009	chemokine activity	IBA	J:265628
Molecular Function	GO:0045236	CXCR chemokine receptor binding	IBA	J:265628
Molecular Function	GO:0048248	CXCR3 chemokine receptor binding	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141392
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:75400
Cellular Component	GO:0005615	extracellular space	IDA	J:143981
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	IBA	J:265628
Biological Process	GO:0097398	cellular response to interleukin-17	IDA	J:269278
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:205449
Biological Process	GO:0070098	chemokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0006935	chemotaxis	ISO	J:164563
Biological Process	GO:0006952	defense response	IEA	J:72247
Biological Process	GO:0051607	defense response to virus	IDA	J:143981
Biological Process	GO:0042118	endothelial cell activation	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0006955	immune response	ISO	J:155856
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0031640	killing of cells of another organism	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0045662	negative regulation of myoblast differentiation	IMP	J:204300
Biological Process	GO:1901740	negative regulation of myoblast fusion	IMP	J:204300
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	ISO	J:155856
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	ISO	J:164563
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:2000406	positive regulation of T cell migration	ISO	J:200103
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:1901509	regulation of endothelial tube morphogenesis	ISO	J:164563
Biological Process	GO:0010819	regulation of T cell chemotaxis	ISO	J:164563
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0010818	T cell chemotaxis	ISO	J:164563