GO Annotations Graph

• Symbol: Nr1h4
• Name: nuclear receptor subfamily 1, group H, member 4
• ID: MGI:1352464

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0032052	bile acid binding	ISO	J:155856
Molecular Function	GO:0032052	bile acid binding	IMP	J:180347
Molecular Function	GO:0032052	bile acid binding	IBA	J:265628
Molecular Function	GO:0038181	bile acid receptor activity	IC	J:180347
Molecular Function	GO:0038181	bile acid receptor activity	ISO	J:164563
Molecular Function	GO:0038181	bile acid receptor activity	ISO	J:155856
Molecular Function	GO:0038181	bile acid receptor activity	IBA	J:265628
Molecular Function	GO:1902122	chenodeoxycholic acid binding	ISO	J:164563
Molecular Function	GO:1902122	chenodeoxycholic acid binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:249196
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:249196
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:73065
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IGI	J:23077
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004879	nuclear receptor activity	IMP	J:180347
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:164563
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:155856
Molecular Function	GO:0004879	nuclear receptor activity	IBA	J:265628
Molecular Function	GO:0004879	nuclear receptor activity	IDA	J:249196
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:249196
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	IDA	J:23077
Molecular Function	GO:0042277	peptide binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:87780
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0000785	chromatin	ISO	J:249196
Cellular Component	GO:0000785	chromatin	IC	J:249196
Cellular Component	GO:0000791	euchromatin	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Biological Process	GO:0015721	bile acid and bile salt transport	ISO	J:155856
Biological Process	GO:0008206	bile acid metabolic process	ISO	J:155856
Biological Process	GO:0008206	bile acid metabolic process	IMP	J:86154
Biological Process	GO:0038183	bile acid signaling pathway	IMP	J:180347
Biological Process	GO:0038183	bile acid signaling pathway	ISO	J:155856
Biological Process	GO:0038183	bile acid signaling pathway	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0007043	cell-cell junction assembly	IMP	J:107133
Biological Process	GO:1903413	cellular response to bile acid	ISO	J:155856
Biological Process	GO:1903413	cellular response to bile acid	ISO	J:164563
Biological Process	GO:0071398	cellular response to fatty acid	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:228561
Biological Process	GO:0071417	cellular response to organonitrogen compound	IMP	J:180347
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:81724
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:155856
Biological Process	GO:0042742	defense response to bacterium	IDA	J:107133
Biological Process	GO:0055089	fatty acid homeostasis	IMP	J:107809
Biological Process	GO:0042593	glucose homeostasis	IDA	J:87780
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0038185	intracellular bile acid receptor signaling pathway	ISO	J:155856
Biological Process	GO:0038185	intracellular bile acid receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001678	intracellular glucose homeostasis	IDA	J:110560
Biological Process	GO:0030522	intracellular receptor signaling pathway	IMP	J:180347
Biological Process	GO:0035356	intracellular triglyceride homeostasis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:228561
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:228561
Biological Process	GO:0050728	negative regulation of inflammatory response	IBA	J:265628
Biological Process	GO:0032692	negative regulation of interleukin-1 production	IMP	J:228561
Biological Process	GO:0032703	negative regulation of interleukin-2 production	IMP	J:228561
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IDA	J:228635
Biological Process	GO:0071638	negative regulation of monocyte chemotactic protein-1 production	IMP	J:228561
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IMP	J:228561
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:180347
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0010868	negative regulation of triglyceride biosynthetic process	ISO	J:155856
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:228561
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	IMP	J:228561
Biological Process	GO:0032689	negative regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:228561
Biological Process	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	ISO	J:249196
Biological Process	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	IDA	J:249196
Biological Process	GO:0001080	nitrogen catabolite activation of transcription from RNA polymerase II promoter	IC	J:180347
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:218171
Biological Process	GO:1904179	positive regulation of adipose tissue development	IMP	J:110560
Biological Process	GO:2001250	positive regulation of ammonia assimilation cycle	IMP	J:180347
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:249196
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:249196
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:2000213	positive regulation of glutamate metabolic process	IMP	J:180347
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	IDA	J:110560
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:161322
Biological Process	GO:0032740	positive regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:1905695	positive regulation of phosphatidic acid biosynthetic process	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:180347
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:211505
Biological Process	GO:0006109	regulation of carbohydrate metabolic process	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	ISO	J:155856
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:164563
Biological Process	GO:0010988	regulation of low-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:23077
Biological Process	GO:0034255	regulation of urea metabolic process	IMP	J:180347
Biological Process	GO:0071873	response to norepinephrine	ISO	J:155856
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0034162	toll-like receptor 9 signaling pathway	IMP	J:195920
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:211505
Biological Process	GO:0070328	triglyceride homeostasis	ISO	J:155856
Biological Process	GO:0070328	triglyceride homeostasis	IDA	J:228417