GO Annotations Graph

• Symbol: Abcc8
• Name: ATP-binding cassette, sub-family C member 8
• ID: MGI:1352629

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043531	ADP binding	IDA	J:34708
Molecular Function	GO:0005524	ATP binding	IDA	J:34708
Molecular Function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0070320	inward rectifier potassium channel inhibitor activity	IDA	J:34708
Molecular Function	GO:0099104	potassium channel activator activity	IDA	J:34708
Molecular Function	GO:0099104	potassium channel activator activity	ISO	J:327473
Molecular Function	GO:0005267	potassium channel activity	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:327473
Cellular Component	GO:0008282	inward rectifying potassium channel	ISO	J:164563
Cellular Component	GO:0008282	inward rectifying potassium channel	ISO	J:155856
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IGI	J:34708
Cellular Component	GO:0005886	plasma membrane	ISO	J:327473
Cellular Component	GO:0005886	plasma membrane	IDA	J:34708
Cellular Component	GO:0005886	plasma membrane	IDA	J:103335
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Biological Process	GO:0071310	cellular response to organic substance	ISO	J:155856
Biological Process	GO:0001678	intracellular glucose homeostasis	ISO	J:155856
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:155856
Biological Process	GO:1905604	negative regulation of blood-brain barrier permeability	ISO	J:155856
Biological Process	GO:0060253	negative regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0046676	negative regulation of insulin secretion	IDA	J:327477
Biological Process	GO:0046676	negative regulation of insulin secretion	IMP	J:144673
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	ISO	J:155856
Biological Process	GO:0061855	negative regulation of neuroblast migration	ISO	J:155856
Biological Process	GO:0050768	negative regulation of neurogenesis	ISO	J:155856
Biological Process	GO:0061045	negative regulation of wound healing	ISO	J:155856
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:144673
Biological Process	GO:0043268	positive regulation of potassium ion transport	ISO	J:155856
Biological Process	GO:1905075	positive regulation of tight junction disassembly	ISO	J:155856
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:1900721	positive regulation of uterine smooth muscle relaxation	ISO	J:155856
Biological Process	GO:1903818	positive regulation of voltage-gated potassium channel activity	ISO	J:155856
Biological Process	GO:0009268	response to pH	ISO	J:155856
Biological Process	GO:0010043	response to zinc ion	ISO	J:155856
Biological Process	GO:0055085	transmembrane transport	IBA	J:265628
Biological Process	GO:0008542	visual learning	ISO	J:155856