GO Annotations Graph

• Symbol: Iqgap1
• Name: IQ motif containing GTPase activating protein 1
• ID: MGI:1352757

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IBA	J:265628
Molecular Function	GO:0005096	GTPase activator activity	IBA	J:265628
Molecular Function	GO:0005078	MAP-kinase scaffold activity	ISO	J:164563
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:200292
Molecular Function	GO:0005515	protein binding	IPI	J:200379
Molecular Function	GO:0005515	protein binding	IPI	J:331467
Molecular Function	GO:0005515	protein binding	IPI	J:243147
Molecular Function	GO:0005515	protein binding	IPI	J:216883
Molecular Function	GO:0005515	protein binding	IPI	J:216883
Molecular Function	GO:0005515	protein binding	IPI	J:145651
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044548	S100 protein binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	IPI	J:145651
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:331467
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:331467
Cellular Component	GO:0005938	cell cortex	IBA	J:265628
Cellular Component	GO:0031252	cell leading edge	IGI	J:105269
Cellular Component	GO:0031252	cell leading edge	IDA	J:216883
Cellular Component	GO:0005911	cell-cell junction	IDA	J:145651
Cellular Component	GO:0030864	cortical actin cytoskeleton	IPI	J:243147
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:81328
Cellular Component	GO:0005737	cytoplasm	IDA	J:216883
Cellular Component	GO:0005737	cytoplasm	IDA	J:145651
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	IDA	J:216883
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0016328	lateral plasma membrane	IDA	J:145651
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005874	microtubule	ISO	J:164563
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:155856
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IGI	J:105269
Cellular Component	GO:0005634	nucleus	IDA	J:255337
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:1990904	ribonucleoprotein complex	IDA	J:174389
Cellular Component	GO:1990904	ribonucleoprotein complex	IGI	J:174389
Cellular Component	GO:0001726	ruffle	ISO	J:164563
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:164563
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	IMP	J:186066
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO	J:164563
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	IMP	J:186066
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	IMP	J:186066
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IMP	J:186066
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IMP	J:186066
Biological Process	GO:0010761	fibroblast migration	IBA	J:265628
Biological Process	GO:0010761	fibroblast migration	IGI	J:216883
Biological Process	GO:1903479	mitotic actomyosin contractile ring assembly actin filament organization	IBA	J:265628
Biological Process	GO:0035305	negative regulation of dephosphorylation	IGI	J:174389
Biological Process	GO:1990138	neuron projection extension	ISO	J:164563
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP	J:186066
Biological Process	GO:1900006	positive regulation of dendrite development	ISO	J:155856
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:155856
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	ISO	J:155856
Biological Process	GO:0045860	positive regulation of protein kinase activity	IMP	J:186066
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0045860	positive regulation of protein kinase activity	IBA	J:265628
Biological Process	GO:1903829	positive regulation of protein localization	ISO	J:155856
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0001817	regulation of cytokine production	IMP	J:174389
Biological Process	GO:0043087	regulation of GTPase activity	IEA	J:72247
Biological Process	GO:0007346	regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:72247