GO Annotations Graph

• Symbol: Eif2ak4
• Name: eukaryotic translation initiation factor 2 alpha kinase 4
• ID: MGI:1353427

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0071074	eukaryotic initiation factor eIF2 binding	IC	J:124910
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	ISO	J:164563
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	IMP	J:129841
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	IMP	J:100646
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	IGI	J:124910
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	IDA	J:227388
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	IDA	J:71261
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	IDA	J:58015
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	IDA	J:227395
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:211861
Molecular Function	GO:0005515	protein binding	IPI	J:218404
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:58015
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0000049	tRNA binding	IDA	J:227388
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0022626	cytosolic ribosome	ISS	J:113815
Cellular Component	GO:0005844	polysome	IDA	J:197824
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0034198	cellular response to amino acid starvation	IDA	J:211861
Biological Process	GO:0034198	cellular response to amino acid starvation	IMP	J:124910
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0070417	cellular response to cold	ISO	J:164563
Biological Process	GO:1990253	cellular response to leucine starvation	IDA	J:197824
Biological Process	GO:0009267	cellular response to starvation	IDA	J:100824
Biological Process	GO:0034644	cellular response to UV	IDA	J:227395
Biological Process	GO:0051607	defense response to virus	IEA	J:60000
Biological Process	GO:0000077	DNA damage checkpoint signaling	IEA	J:72247
Biological Process	GO:0036492	eiF2alpha phosphorylation in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IMP	J:107108
Biological Process	GO:0140469	GCN2-mediated signaling	IMP	J:100646
Biological Process	GO:0140469	GCN2-mediated signaling	IDA	J:71261
Biological Process	GO:0140469	GCN2-mediated signaling	IMP	J:227362
Biological Process	GO:0140469	GCN2-mediated signaling	ISO	J:164563
Biological Process	GO:0140469	GCN2-mediated signaling	IMP	J:129841
Biological Process	GO:0140469	GCN2-mediated signaling	IMP	J:99455
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0007612	learning	IMP	J:100646
Biological Process	GO:0007616	long-term memory	IMP	J:100646
Biological Process	GO:0044828	negative regulation by host of viral genome replication	IDA	J:227388
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	IMP	J:100646
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:197824
Biological Process	GO:0017148	negative regulation of translation	IGI	J:107108
Biological Process	GO:0045947	negative regulation of translational initiation	IDA	J:227388
Biological Process	GO:0032057	negative regulation of translational initiation in response to stress	IDA	J:227395
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:1990138	neuron projection extension	IMP	J:197824
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0002821	positive regulation of adaptive immune response	IMP	J:205264
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IDA	J:227388
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:124910
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	IMP	J:100646
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0071264	positive regulation of translational initiation in response to starvation	IDA	J:71261
Biological Process	GO:0071264	positive regulation of translational initiation in response to starvation	IMP	J:100646
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:71261
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:227388
Biological Process	GO:0006468	protein phosphorylation	IMP	J:100646
Biological Process	GO:0006468	protein phosphorylation	IMP	J:129841
Biological Process	GO:0006468	protein phosphorylation	IDA	J:58015
Biological Process	GO:0006468	protein phosphorylation	IMP	J:99455
Biological Process	GO:0060259	regulation of feeding behavior	IMP	J:129841
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0006446	regulation of translational initiation	ISS	J:58015
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	IDA	J:227388
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	ISO	J:164563
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	IDA	J:227395
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	IMP	J:227362
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	IMP	J:100646
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	IGI	J:124910
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	IMP	J:99455
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	IDA	J:71261
Biological Process	GO:0043558	regulation of translational initiation in response to stress	IDA	J:100824
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IGI	J:124910
Biological Process	GO:0002286	T cell activation involved in immune response	IMP	J:205264
Biological Process	GO:0019081	viral translation	IDA	J:227388