GO Annotations Graph

• Symbol: Pcsk1n
• Name: proprotein convertase subtilisin/kexin type 1 inhibitor
• ID: MGI:1353431

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004866	endopeptidase inhibitor activity	ISO	J:155856
Molecular Function	GO:0004866	endopeptidase inhibitor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:259508
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IDA	J:59330
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:59330
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0030141	secretory granule	IDA	J:59330
Cellular Component	GO:0005802	trans-Golgi network	IDA	J:59330
Biological Process	GO:0010951	negative regulation of endopeptidase activity	IEA	J:72247
Biological Process	GO:0007218	neuropeptide signaling pathway	IEA	J:60000
Biological Process	GO:0016486	peptide hormone processing	IDA	J:59330
Biological Process	GO:0009409	response to cold	IDA	J:109670
Biological Process	GO:0002021	response to dietary excess	IDA	J:109670