GO Annotations Graph

• Symbol: Eif2ak1
• Name: eukaryotic translation initiation factor 2 alpha kinase 1
• ID: MGI:1353448

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	ISO	J:155856
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	ISO	J:164563
Molecular Function	GO:0020037	heme binding	IDA	J:113875
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200502
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:114048
Molecular Function	GO:0004672	protein kinase activity	IBA	J:265628
Molecular Function	GO:0004672	protein kinase activity	IMP	J:85896
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:113887
Cellular Component	GO:0005737	cytoplasm	IDA	J:127433
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9655549
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9655598
Biological Process	GO:0002526	acute inflammatory response	IMP	J:127433
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:127433
Biological Process	GO:0140468	HRI-mediated signaling	ISO	J:164563
Biological Process	GO:0140467	integrated stress response signaling	ISO	J:164563
Biological Process	GO:0030225	macrophage differentiation	IMP	J:127433
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:127433
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:127433
Biological Process	GO:0008285	negative regulation of cell population proliferation	IDA	J:113887
Biological Process	GO:0046986	negative regulation of hemoglobin biosynthetic process	IDA	J:113887
Biological Process	GO:0017148	negative regulation of translation	IEA	J:60000
Biological Process	GO:0006909	phagocytosis	IMP	J:127433
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0046777	protein autophosphorylation	IEP	J:114048
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0046501	protoporphyrinogen IX metabolic process	IGI	J:99200
Biological Process	GO:0046501	protoporphyrinogen IX metabolic process	IGI	J:99200
Biological Process	GO:0010999	regulation of eIF2 alpha phosphorylation by heme	IGI	J:99200
Biological Process	GO:0010999	regulation of eIF2 alpha phosphorylation by heme	IGI	J:99200
Biological Process	GO:0046984	regulation of hemoglobin biosynthetic process	IGI	J:99200
Biological Process	GO:0046984	regulation of hemoglobin biosynthetic process	IGI	J:99200
Biological Process	GO:0006417	regulation of translation	IMP	J:85896
Biological Process	GO:1990641	response to iron ion starvation	ISO	J:164563