GO Annotations Graph

• Symbol: Eif2ak2
• Name: eukaryotic translation initiation factor 2-alpha kinase 2
• ID: MGI:1353449

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003725	double-stranded RNA binding	IDA	J:173994
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:170947
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:186690
Molecular Function	GO:0005515	protein binding	IPI	J:161178
Molecular Function	GO:0005515	protein binding	IPI	J:189981
Molecular Function	GO:0005515	protein binding	IPI	J:196116
Molecular Function	GO:0005515	protein binding	IPI	J:19621
Molecular Function	GO:0005515	protein binding	IPI	J:57775
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IMP	J:167126
Molecular Function	GO:0004672	protein kinase activity	IBA	J:265628
Molecular Function	GO:0004672	protein kinase activity	IDA	J:19621
Molecular Function	GO:0004672	protein kinase activity	IDA	J:94421
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Biological Process	GO:0140374	antiviral innate immune response	ISO	J:164563
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IEA	J:60000
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:94221
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IGI	J:94221
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	ISO	J:164563
Biological Process	GO:0017148	negative regulation of translation	ISO	J:164563
Biological Process	GO:0045071	negative regulation of viral genome replication	ISO	J:164563
Biological Process	GO:0045071	negative regulation of viral genome replication	IMP	J:196269
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:196269
Biological Process	GO:0001819	positive regulation of cytokine production	IMP	J:196269
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IMP	J:196269
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	IMP	J:196269
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:186690
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:94221
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:19621
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:94221
Biological Process	GO:0006468	protein phosphorylation	IDA	J:19621
Biological Process	GO:1901532	regulation of hematopoietic progenitor cell differentiation	IMP	J:196300
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	IMP	J:196300
Biological Process	GO:1902033	regulation of hematopoietic stem cell proliferation	IMP	J:196300
Biological Process	GO:1900225	regulation of NLRP3 inflammasome complex assembly	IMP	J:186690
Biological Process	GO:0035455	response to interferon-alpha	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0009636	response to toxic substance	ISO	J:155856
Biological Process	GO:0009615	response to virus	ISO	J:164563
Biological Process	GO:0033197	response to vitamin E	ISO	J:155856
Biological Process	GO:0006412	translation	IDA	J:19621