GO Annotations Graph

• Symbol: Apln
• Name: apelin
• ID: MGI:1353624

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031704	apelin receptor binding	ISO	J:164563
Molecular Function	GO:0031704	apelin receptor binding	ISO	J:155856
Molecular Function	GO:0005179	hormone activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:50460
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0060183	apelin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0060183	apelin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0060183	apelin receptor signaling pathway	IDA	J:241486
Biological Process	GO:0060976	coronary vasculature development	IMP	J:245878
Biological Process	GO:0042756	drinking behavior	ISO	J:155856
Biological Process	GO:0007631	feeding behavior	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:50460
Biological Process	GO:0007369	gastrulation	IEA	J:60000
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0045776	negative regulation of blood pressure	ISO	J:155856
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	ISO	J:155856
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0045906	negative regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0051461	positive regulation of corticotropin secretion	ISO	J:155856
Biological Process	GO:0051466	positive regulation of corticotropin-releasing hormone secretion	ISO	J:155856
Biological Process	GO:1904022	positive regulation of G protein-coupled receptor internalization	ISO	J:164563
Biological Process	GO:1904022	positive regulation of G protein-coupled receptor internalization	IDA	J:241486
Biological Process	GO:1904022	positive regulation of G protein-coupled receptor internalization	ISO	J:155856
Biological Process	GO:0045823	positive regulation of heart contraction	ISO	J:155856
Biological Process	GO:0010460	positive regulation of heart rate	ISO	J:155856
Biological Process	GO:0031652	positive regulation of heat generation	ISO	J:155856
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:155856
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0050878	regulation of body fluid levels	ISO	J:155856
Biological Process	GO:0002026	regulation of the force of heart contraction	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247