GO Annotations Graph

• Symbol: Usp25
• Name: ubiquitin specific peptidase 25
• ID: MGI:1353655

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IBA	J:265628
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	ISS	J:60249
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0032183	SUMO binding	ISO	J:164563
Molecular Function	GO:0032183	SUMO binding	IBA	J:265628
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0000502	proteasome complex	ISS	J:60249
Biological Process	GO:0032602	chemokine production	IMP	J:188557
Biological Process	GO:0001816	cytokine production	IMP	J:188557
Biological Process	GO:0007252	I-kappaB phosphorylation	IMP	J:188557
Biological Process	GO:0006955	immune response	IMP	J:188557
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	IMP	J:188557
Biological Process	GO:0097400	interleukin-17-mediated signaling pathway	IDA	J:188557
Biological Process	GO:0016071	mRNA metabolic process	IMP	J:188557
Biological Process	GO:1904293	negative regulation of ERAD pathway	ISO	J:164563
Biological Process	GO:0016579	protein deubiquitination	ISO	J:164563
Biological Process	GO:0016579	protein deubiquitination	IBA	J:265628
Biological Process	GO:0071108	protein K48-linked deubiquitination	ISO	J:164563
Biological Process	GO:0070536	protein K63-linked deubiquitination	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0031647	regulation of protein stability	IBA	J:265628
Biological Process	GO:0006979	response to oxidative stress	IMP	J:201237
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	IMP	J:188557
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISS	J:60249